Table 6. Haplotype associations
| Haplotypes |
Cases |
Controls |
Odds ratios |
Cases |
Controls |
Odds ratios |
|
|
1. Swedish set A |
2. Scottish set B |
| H1-AAT |
202 (0.50) |
150 (0.45) |
1.2 (0.91–1.6; 0.18) |
126 (0.52) |
134 (0.44) |
1.4 (0.97–1.9; 0.076) |
| H2-GTC |
136 (0.33) |
130 (0.39) |
0.8 (0.59–1.1; 0.12) |
77 (0.31) |
104 (0.34) |
0.9 (0.62–1.3; 0.51) |
| H3-GAT |
37 (0.09) |
26 (0.08) |
NP |
22 (0.09) |
26 (0.09) |
NP |
| H4-GAC |
16 (0.04) |
19 (0.06) |
NP |
10 (0.04) |
23 (0.08) |
NP |
| H5-ATC |
4 (0.01) |
5 (0.01) |
NP |
5 (0.02) |
7 (0.02) |
NP |
| H6-GTT |
2 (0.01) |
0 |
NP |
0 |
5 (0.01) |
NP |
| H7-AAC |
11 (0.03) |
6 (0.02) |
NP |
0 |
0 |
NP |
|
3. Swedish set C |
4. English set D |
| H1-AAT |
178 (0.49) |
279 (0.43) |
1.3 (0.97–1.6; 0.079) |
298 (0.47) |
87 (0.41) |
1.3 (0.93–1.7; 0.13) |
| H2-GTC |
112 (0.31) |
228 (0.35) |
0.8 (0.62–1.1; 0.14) |
217 (0.34) |
84 (0.39) |
0.8 (0.57–1.1; 0.16) |
| H3-GAT |
30 (0.08) |
66 (0.10) |
NP |
62 (0.10) |
20 (0.09) |
NP |
| H4-GAC |
28 (0.08) |
45 (0.07) |
NP |
37 (0.06) |
12 (0.06) |
NP |
| H5-ATC |
4 (0.01) |
11 (0.02) |
NP |
4 (0.01) |
6 (0.03) |
NP |
| H6-GTT |
3 (0.01) |
2 (0.003) |
NP |
6 (0.01) |
0 |
NP |
| H7-AAC |
9 (0.02) |
15 (0.02) |
NP |
15 (0.02) |
5 (0.02) |
NP |
|
5. Sets A+B+C+D |
6. Sets A+B+C+D+E |
| H1-AAT |
804 (0.49) |
648 (0.44) |
1.2 (1.1–1.4; 0.0039) |
804 (0.49) |
1985 (0.44) |
1.2 (1.1–1.3; 0.0031) |
| H2-GTC |
542 (0.33) |
544 (0.37) |
0.8 (0.73–0.97; 0.028) |
542 (0.33) |
1533 (0.34) |
NS |
| H3-GAT |
151 (0.09) |
137 (0.09) |
NS |
151 (0.09) |
399 (0.09) |
NS |
| H4-GAC |
91 (0.06) |
98 (0.07) |
NS |
91 (0.06) |
307 (0.07) |
NS |
| H5-ATC |
17 (0.01) |
29 (0.02) |
0.5 (0.28–0.93; 0.026) |
17 (0.01) |
103 (0.02) |
0.4 (0.26–0.74; 0.0014) |
| H6-GTT |
11 (0.01) |
7 (0.01) |
NS |
11 (0.01) |
34 (0.01) |
NS |
| H7-AAC |
35 (0.02) |
25 (0.02) |
NS |
35 (0.02) |
104 (0.02) |
NS |
|
Haplotype counts (frequency) for each phenotypic group are shown, along with odds ratios and their associated 95% confidence intervals and P-values (calculated using the chi-square statistic on 2x2 contingency tables and comparing haplotypes in each row against all other haplotypes). For panels 1–4, only comparisons involving the first two haplotypes were performed and all results are shown. For panels 5 and 6, comparisons were performed for all individual haplotypes and only results with significance levels below P=0.05 are shown. NP=not performed. NS=not significant.