© 1992 Oxford University Press
OTHER |
Isolation and characterization of 19 dinucleotide repeat polymorphisms on chromosome 3p
Department of Biochemistry, Cancer Institute 1-37-1, Kami-lkebukuro, Toshima-ku, Tokyo 170, Japan
*To whom correspondence should be addressed
Received March 3, 1992; Revised March 17, 1992; Accepted March 17, 1992
We have screened cosmids on chromosome 3p for (dC-dA)n·(dG-dT)n dinudeotide-repeat sequences. Eighty-nine of 155 cosmids (58%) contained (dC-dA)n·(dG-dT(n repeats as determined by colony hybridization with a (dG-dT)10 oligonucleotide probe; 29 of these were subcloned and the sequences flanking the dinucleotide repeats were determined. Nineteen of the 24 loci examined for polymorphisms by PCR were found to be polymorphic with heterozygosities ranging from 3% to 86%. These dinucleotide repeat polymorphisms will be useful markers for high-resolution mapping of genes that have been localized to 3p, including tumour suppressor genes associated with several types of cancer and genes responsible for various hereditary disorders, such as von Hippel—Lindau disease.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C Cybulski, K Krzystolik, A Murgia, B Gorski, T Debniak, A Jakubowska, M Martella, G Kurzawski, M Prost, I Kojder, et al. Germline mutations in the von Hippel-Lindau (VHL) gene in patients from Poland: disease presentation in patients with deletions of the entire VHL gene J. Med. Genet., July 1, 2002; 39(7): e38 - 38. [Full Text] [PDF]
|
|
|
|
 |
|
 S Glasker, B U Bender, T W Apel, V van Velthoven, L M Mulligan, J Zentner, and H P H Neumann Reconsideration of biallelic inactivation of the VHL tumour suppressor gene in hemangioblastomas of the central nervous system J. Neurol. Neurosurg. Psychiatry, May 1, 2001; 70(5): 644 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Washington, F. Dalbegue, F. Abreo, J. K. Taubenberger, and J. H. Lichy Loss of Heterozygosity in Fibrocystic Change of the Breast : Genetic Relationship Between Benign Proliferative Lesions and Associated Carcinomas Am. J. Pathol., July 1, 2000; 157(1): 323 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Webster, E. R. Maher, and A. T. Moore Clinical Characteristics of Ocular Angiomatosis in von Hippel-Lindau Disease and Correlation With Germline Mutation Arch Ophthalmol, March 1, 1999; 117(3): 371 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R Webster, R. B Fisher, L. Ginsberg, and E. R Maher Independent segregation of von Hippel-Lindau disease and cerebral cavernomas J. Neurol. Neurosurg. Psychiatry, November 1, 1997; 63(5): 665 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hung, Y. Kishimoto, K. Sugio, A. Virmani, D. D. Mclntire, J. D. Minna, and A. F. Gazdar Allele-Specific Chromosome 3p Deletions Occur at an Early Stage in the Pathogenesis of Lung Carcinoma JAMA, February 15, 1995; 273(7): 558 - 563. [Abstract] [PDF]
|
|
|
|
 |
|
 D. I. Smith and M. del Mar Alonso Cloning of Tumor Suppressor Genes Involved in Solid Tumor Development Arch Otolaryngol Head Neck Surg, November 1, 1993; 119(11): 1210 - 1216. [Abstract] [PDF]
|
|
|
|
 |
|
 X. Hu, T. Pang, A. Asplund, J. Ponten, and M. Nister Clonality Analysis of Synchronous Lesions of Cervical Carcinoma Based on X Chromosome Inactivation Polymorphism, Human Papillomavirus Type 16 Genome Mutations, and Loss of Heterozygosity J. Exp. Med., March 25, 2002; 195(7): 845 - 854. [Abstract] [Full Text] [PDF]
|
|