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© 1992 Oxford University Press

OTHER

Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA

Rebecca J. Oakey, Mark L. Watson and Michael F. Seldin*

Department of Medicine and Department of Microbiology and Immunology, Duke University Medical Center Durham, NC 27710, USA

* Duke University Medical Center, Box 3880, Room 247 CARL, Durham, NC 27710, USA

Received July 20, 1992; Revised September 17, 1992; Accepted September 17, 1992

Long range restriction site maps of 13 Mb of mouse chromosome 1 and 11 Mb of human chromosome 1 were constructed using a framework provided by a detailed mouse genetic map. Where an unambiguous gene order could be determined in both species (14 genes), the human and mouse orders were identical. In addition, the distances between markers in the mouse and human were similar except for one region of the conserved linkage group where we could detect a larger distance in the mouse compared to the human. These data support the use of comparative mapping in physical map construction and further suggest the value of using mouse genetics to help define human disease loci.


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