Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ambrose, C.
Right arrow Articles by MacDonald, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ambrose, C.
Right arrow Articles by MacDonald, M. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 Oxford University Press

RESEARCH-ARTICLE

A novel G protein-coupled receptor kinase gene cloned from 4p16.3

Christine Ambrose, Marianne James, Glenn Barnes, Carol Lin, Gillian Bates1, Michael Altherr2, Mabel Duyao, Nicolet Groot, Deanna Church, John J. Wasmuth2, Hans Lehrach1, David Housman3, Alan Buckler, James F. Gusella and Marcy E. MacDonald*

Molecular Neurogenetics Unit, Massachusetts General Hospital and Department of Genetics, Harvard Medical School Boston, MA 02114, USA 1Imperial Cancer Research Fund Licoln's Inn Fields, London, WC2A 3PX, UK 2Department of Biological Chemistry University of Calitornia, Irvine, CA 92717 3Center for Cancer Research, Massachusetts Institute of Technology Cambridge, MA, USA

* To whom correspondence should be addressed at: Molecular Neurogenetics Laboratory, Massachusetts General Hospital East, Building 149, 13th Street Charlestown, MA 02129, USA

Received September 3, 1992; Revised October 7, 1992; Accepted October 7, 1992

Within the Huntington's disease (HD) candidate region of 4pl6.3, the D4S127 locus displays strong linkage disequilibrium with the defect and anchors a conserved haplotype found on many HD chromosomes. To isolate genes from this region we have applied the exon amplification technique to overlapping cosmids spanning D4S127. Here, we report the discovery of a new gene encoding a novel member of a family of protein kinases that specifically phosphorylate the activated forms of G protein-coupled receptors. Such kinases are thought to participate in desensitization of specific receptors, thereby blocking further signal transduction. This gene must now be carefully scrutinized to determine whether it might be involved in HD.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Wang, I. Armando, L. D. Asico, C. Escano, X. Wang, Q. Lu, R. A. Felder, C. G. Schnackenberg, D. R. Sibley, G. M. Eisner, et al.
The elevated blood pressure of human GRK4{gamma} A142V transgenic mice is not associated with increased ROS production
Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2083 - H2092.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. L. Rankin, P. S. Marinec, D. M. Cabrera, Z. Wang, P. A. Jose, and D. R. Sibley
The D1 Dopamine Receptor Is Constitutively Phosphorylated by G Protein-Coupled Receptor Kinase 4
Mol. Pharmacol., March 1, 2006; 69(3): 759 - 769.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
K. A. Neve
Novel Features of G Protein-Coupled Receptor Kinase 4
Mol. Pharmacol., March 1, 2006; 69(3): 673 - 676.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Pi, R. H. Oakley, D. Gesty-Palmer, R. D. Cruickshank, R. F. Spurney, L. M. Luttrell, and L. D. Quarles
{beta}-Arrestin- and G Protein Receptor Kinase-Mediated Calcium-Sensing Receptor Desensitization
Mol. Endocrinol., April 1, 2005; 19(4): 1078 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Iacovelli, L. Salvatore, L. Capobianco, A. Picascia, E. Barletta, M. Storto, S. Mariggio, M. Sallese, A. Porcellini, F. Nicoletti, et al.
Role of G Protein-coupled Receptor Kinase 4 and beta -Arrestin 1 in Agonist-stimulated Metabotropic Glutamate Receptor 1 Internalization and Activation of Mitogen-activated Protein Kinases
J. Biol. Chem., March 28, 2003; 278(14): 12433 - 12442.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J. M. Willets, R. A. J. Challiss, E. Kelly, and S. R. Nahorski
G Protein-Coupled Receptor Kinases 3 and 6 Use Different Pathways to Desensitize the Endogenous M3 Muscarinic Acetylcholine Receptor in Human SH-SY5Y Cells
Mol. Pharmacol., August 1, 2001; 60(2): 321 - 330.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. SALLESE, L. SALVATORE, E. D’URBANO, G. SALA, M. STORTO, T. LAUNEY, F. NICOLETTI, T. KNÖPFEL, and A. DE BLASI
The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1
FASEB J, December 1, 2000; 14(15): 2569 - 2580.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
R. T. Premont, A. D. Macrae, S. A. J. R. Aparicio, H. E. Kendall, J. E. Welch, and R. J. Lefkowitz
The GRK4 Subfamily of G Protein-coupled Receptor Kinases. ALTERNATIVE SPLICING, GENE ORGANIZATION, AND SEQUENCE CONSERVATION
J. Biol. Chem., October 8, 1999; 274(41): 29381 - 29389.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
M. Centola, X. Chen, R. Sood, Z. Deng, I. Aksentijevich, T. Blake, D. O. Ricke, X. Chen, G. Wood, N. Zaks, et al.
Construction of an ~700-kb Transcript Map Around the Familial Mediterranean Fever Locus on Human Chromosome 16p13.3
Genome Res., November 1, 1998; 8(11): 1172 - 1191.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J. L. R. Freeman, E. M. D. L. Cruz, T. D. Pollard, R. J. Lefkowitz, and J. A. Pitcher
Regulation of G protein-coupled Receptor Kinase 5 (GRK5) by Actin
J. Biol. Chem., August 7, 1998; 273(32): 20653 - 20657.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Virlon, D. Firsov, L. Cheval, E. Reiter, C. Troispoux, F. Guillou, and J.-M. Elalouf
Rat G Protein-Coupled Receptor Kinase GRK4: Identification, Functional Expression, and Differential Tissue Distribution of Two Splice Variants
Endocrinology, June 1, 1998; 139(6): 2784 - 2795.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Kikkawa, N. Yoshida, M. Nakagawa, T. Iwasa, and M. Tsuda
A Novel Rhodopsin Kinase in Octopus Photoreceptor Possesses a Pleckstrin Homology Domain and Is Activated by G Protein beta gamma -Subunits
J. Biol. Chem., March 27, 1998; 273(13): 7441 - 7447.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Zhao, J. Huang, S. C. Khani, and K. Palczewski
Molecular Forms of Human Rhodopsin Kinase (GRK1)
J. Biol. Chem., February 27, 1998; 273(9): 5124 - 5131.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. J. Mundell, J. L. Benovic, and E. Kelly
A Dominant Negative Mutant of the G Protein-Coupled Receptor Kinase 2 Selectively Attenuates Adenosine A2 Receptor Desensitization
Mol. Pharmacol., June 1, 1997; 51(6): 991 - 998.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
M. Sallese, S. Mariggio, G. Collodel, E. Moretti, P. Piomboni, B. Baccetti, and A. De Blasi
G Protein-coupled Receptor Kinase GRK4. MOLECULAR ANALYSIS OF THE FOUR ISOFORMS AND ULTRASTRUCTURAL LOCALIZATION IN SPERMATOZOA AND GERMINAL CELLS
J. Biol. Chem., April 11, 1997; 272(15): 10188 - 10195.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. W. McGraw and S. B. Liggett
Heterogeneity in beta -Adrenergic Receptor Kinase Expression in the Lung Accounts for Cell-specific Desensitization of the beta 2-Adrenergic Receptor
J. Biol. Chem., March 14, 1997; 272(11): 7338 - 7344.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. K. DebBurman, J. Ptasienski, J. L. Benovic, and M. M. Hosey
G Protein-coupled Receptor Kinase GRK2 Is a Phospholipid-dependent Enzyme That Can Be Conditionally Activated by G Protein beta gamma Subunits
J. Biol. Chem., September 13, 1996; 271(37): 22552 - 22562.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
T C Burn, T D Connors, T J Van Raay, W R Dackowski, J M Millholland, K W Klinger, and G M Landes
Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.
Genome Res., June 1, 1996; 6(6): 525 - 537.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Nagayama, K. Tanaka, T. Hara, H. Namba, S. Yamashita, K. Taniyama, and M. Niwa
Involvement of G Protein-coupled Receptor Kinase 5 in Homologous Desensitization of the Thyrotropin Receptor
J. Biol. Chem., April 26, 1996; 271(17): 10143 - 10148.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. T. Premont, A. D. Macrae, R. H. Stoffel, N. Chung, J. A. Pitcher, C. Ambrose, J. Inglese, M. E. MacDonald, and R. J. Lefkowitz
Characterization of the G Protein-coupled Receptor Kinase GRK4
J. Biol. Chem., March 15, 1996; 271(11): 6403 - 6410.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Diviani, A.-L. Lattion, N. Larbi, P. Kunapuli, A. Pronin, J. L. Benovic, and S. Cotecchia
Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the alpha[IMAGE]-Adrenergic Receptor
J. Biol. Chem., March 1, 1996; 271(9): 5049 - 5058.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. K. DebBurman, J. Ptasienski, E. Boetticher, J. W. Lomasney, J. L. Benovic, and M. M. Hosey
Lipid-mediated Regulation of G Protein-coupled Receptor Kinases 2 and 3
J. Biol. Chem., March 17, 1995; 270(11): 5742 - 5747.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. Casari, C. Barlassina, D. Cusi, L. Zagato, R. Muirhead, M. Righetti, P. Nembri, K. Amar, M. Gatti, F. Macciardi, et al.
Association of the {alpha}-Adducin Locus With Essential Hypertension
Hypertension, March 1, 1995; 25(3): 320 - 326.
[Abstract] [Full Text]

Home page
 Arch NeurolHome page
J. F. Gusella, M. E. MacDonald, C. M. Ambrose, and M. P. Duyao
Molecular Genetics of Huntington's Disease
Arch Neurol, November 1, 1993; 50(11): 1157 - 1163.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
K. Berrada, C. L. Plesnicher, X. Luo, and M. Thibonnier
Dynamic Interaction of Human Vasopressin/Oxytocin Receptor Subtypes with G Protein-coupled Receptor Kinases and Protein Kinase C after Agonist Stimulation
J. Biol. Chem., August 25, 2000; 275(35): 27229 - 27237.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.