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Human Molecular Genetics, 2001, Vol. 10, No. 17 1847-1851
© 2001 Oxford University Press

{alpha}-synuclein gene haplotypes are associated with Parkinson’s disease

Matt Farrer, Demetrius M. Maraganore1, Paul Lockhart, Andrew Singleton, T.G. Lesnick2, Mariza de Andrade2, Andrew West, Rohan de Silva3, John Hardy+ and Dena Hernandez

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA, 1Department of Neurology and 2Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA and 3Reta Lila Weston Institute of Neurological Studies, 46 Cleveland Street, London W1T 4JF, UK

We report haplotype analysis of the {alpha}-synuclein gene in Parkinson’s disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the {alpha}-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.

+ To whom correspondence should be addressed. Tel: +1 904 953 7356; Fax: +1 904 953 7370; Email: hardy@mayo.edu


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