Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (51)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kondrashov, F. A.
Right arrow Articles by Koonin, E. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kondrashov, F. A.
Right arrow Articles by Koonin, E. V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, 2001, Vol. 10, No. 23 2661-2669
© 2001 Oxford University Press

Origin of alternative splicing by tandem exon duplication

Fyodor A. Kondrashov and Eugene V. Koonin+

National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA

Genes with new functions often evolve by gene duplication. Alternative splicing is another means of evolutionary innovation in eukaryotes, which allows a single gene to encode functionally diverse proteins. We investigate a connection between these two evolutionary phenomena. For ~10% of the described cases of substitution alternative splicing, such that either one or another amino acid sequence is included into the protein, evidence of origin by tandem exon duplication was found. This is a conservative estimate because alternative exons are typically short and, on many occasions, duplicates may have diverged beyond recognition. Dating exon duplications through a combination of the available experimental data on alternative splicing in orthologous genes from different species and computational analysis indicates that most of the duplications antedate at least the radiation of mammalian orders or even the radiation of vertebrate classes. At present, tandem exon duplication is the only mechanism of evolution of substitution alternative splicing that can be specifically demonstrated. Along with gene duplication, this could be a major route for generating functional diversity during evolution of multicellular eukaryotes.

+ To whom correspondence should be addressed. Tel: +1 301 535 5913; Fax: +1 301 435 7794; Email: koonin@ncbi.nlm.nih.gov


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J HeredHome page
F. Catania, X. Gao, and D. G. Scofield
Endogenous Mechanisms for the Origins of Spliceosomal Introns
J. Hered., September 1, 2009; 100(5): 591 - 596.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
L. Lin, P. Jiang, S. Shen, S. Sato, B. L. Davidson, and Y. Xing
Large-scale analysis of exonized mammalian-wide interspersed repeats in primate genomes
Hum. Mol. Genet., June 15, 2009; 18(12): 2204 - 2214.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. Irimia, J. L. Rukov, D. Penny, J. Garcia-Fernandez, J. Vinther, and S. W. Roy
Widespread Evolutionary Conservation of Alternatively Spliced Exons in Caenorhabditis
Mol. Biol. Evol., February 1, 2008; 25(2): 375 - 382.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
R. Sorek
The birth of new exons: Mechanisms and evolutionary consequences
RNA, October 1, 2007; 13(10): 1603 - 1608.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
A. V. Alekseyenko, N. Kim, and C. J. Lee
Global analysis of exon creation versus loss and the role of alternative splicing in 17 vertebrate genomes
RNA, May 1, 2007; 13(5): 661 - 670.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Zhuo, R. Madden, S. A. Elela, and B. Chabot
Modern origin of numerous alternatively spliced human introns from tandem arrays
PNAS, January 16, 2007; 104(3): 882 - 886.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
K. D. Holland, M. T. Fleming, S. Cheek, J. L. Moran, D. R. Beier, and M. H. Meisler
De Novo Exon Duplication in a New Allele of Mouse Glra1 (Spasmodic)
Genetics, December 1, 2006; 174(4): 2245 - 2247.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
A. K. Jones, V. Raymond-Delpech, S. H. Thany, M. Gauthier, and D. B. Sattelle
The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera
Genome Res., November 1, 2006; 16(11): 1422 - 1430.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
R. Gopalapillai, K. Kadono-Okuda, K. Tsuchida, K. Yamamoto, J. Nohata, M. Ajimura, and K. Mita
Lipophorin receptor of Bombyx mori: cDNA cloning, genomic structure, alternative splicing, and isolation of a new isoform
J. Lipid Res., May 1, 2006; 47(5): 1005 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
D. B. Malko, V. J. Makeev, A. A. Mironov, and M. S. Gelfand
Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes
Genome Res., April 1, 2006; 16(4): 505 - 509.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
X. Shao, V. Shepelev, and A. Fedorov
Bioinformatic analysis of exon repetition, exon scrambling and trans-splicing in humans
Bioinformatics, March 15, 2006; 22(6): 692 - 698.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
C. L. ZHENG, X.-D. FU, and M. GRIBSKOV
Characteristics and regulatory elements defining constitutive splicing and different modes of alternative splicing in human and mouse
RNA, December 1, 2005; 11(12): 1777 - 1787.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
B. P. Cusack and K. H. Wolfe
Changes in Alternative Splicing of Human and Mouse Genes Are Accompanied by Faster Evolution of Constitutive Exons
Mol. Biol. Evol., November 1, 2005; 22(11): 2198 - 2208.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Xing and C. Lee
Colloquium Paper: Evidence of functional selection pressure for alternative splicing events that accelerate evolution of protein subsequences
PNAS, September 20, 2005; 102(38): 13526 - 13531.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
W. Wang, H. Zheng, S. Yang, H. Yu, J. Li, H. Jiang, J. Su, L. Yang, J. Zhang, J. McDermott, et al.
Origin and evolution of new exons in rodents
Genome Res., September 1, 2005; 15(9): 1258 - 1264.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
B. R. GRAVELEY, A. KAUR, D. GUNNING, S. L. ZIPURSKY, L. ROWEN, and J. C. CLEMENS
The organization and evolution of the Dipteran and Hymenopteran Down syndrome cell adhesion molecule (Dscam) genes
RNA, October 20, 2004; 10(10): 1499 - 1506.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
Y. Zhuang, F. Ma, J. Li-Ling, X. Xu, and Y. Li
Comparative Analysis of Amino Acid Usage and Protein Length Distribution Between Alternatively and Non-alternatively Spliced Genes Across Six Eukaryotic Genomes
Mol. Biol. Evol., December 1, 2003; 20(12): 1978 - 1985.
[Abstract] [Full Text] [PDF]

Home page
 Protein Eng Des SelHome page
K. Kitamura, Y. Kinoshita, S. Narasaki, N. Nemoto, Y. Husimi, and K. Nishigaki
Construction of block-shuffled libraries of DNA for evolutionary protein engineering: Y-ligation-based block shuffling
Protein Eng. Des. Sel., October 1, 2002; 15(10): 843 - 853.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
I. Letunic, R. R. Copley, and P. Bork
Common exon duplication in animals and its role in alternative splicing
Hum. Mol. Genet., June 15, 2002; 11(13): 1561 - 1567.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.