Human Molecular Genetics, 2001, Vol. 10, No. 5 507-512
© 2001 Oxford University Press
The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti
1MRC Mammalian Genetics Unit and Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK, 2MRC Institute of Hearing Research, Nottingham NG7 2RD, UK, 3Department of Biotechnology and Genetics and 4Department of Neuroscience, SmithKline Beecham Pharmaceuticals, Essex CM19 5AW, UK
The Notch signalling pathway has recently been implicated in the development and patterning of the sensory epithelium in the cochlea, the organ of Corti. As part of an ongoing large-scale mutagenesis programme to identify new deaf or vestibular mouse mutants, we have identified a novel mouse mutant, slalom, which shows abnormalities in the patterning of hair cells in the organ of Corti and missing ampullae, structures that house the sensory epithelia of the semicircular canals. We show that the slalom mutant carries a mutation in the Jagged1 gene, implicating a new ligand in the signalling processes that pattern the inner ear neuro-epithelium.
+ These authors contributed equally to this work
§ To whom correspondence should be addressed. Tel: +44 1235 824541; Fax: +44 1235 824542; Email: s.brown@har.mrc.ac.uk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. E. Kiernan, R. Li, N. L. Hawes, G. A. Churchill, and T. Gridley Genetic Background Modifies Inner Ear and Eye Phenotypes of Jag1 Heterozygous Mice Genetics, September 1, 2007; 177(1): 307 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Daudet, L. Ariza-McNaughton, and J. Lewis Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear Development, June 15, 2007; 134(12): 2369 - 2378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schwander, A. Sczaniecka, N. Grillet, J. S. Bailey, M. Avenarius, H. Najmabadi, B. M. Steffy, G. C. Federe, E. A. Lagler, R. Banan, et al. A Forward Genetics Screen in Mice Identifies Recessive Deafness Traits and Reveals That Pejvakin Is Essential for Outer Hair Cell Function J. Neurosci., February 28, 2007; 27(9): 2163 - 2175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Tang, H. M. Alger, and F. A. Pereira COUP-TFI controls Notch regulation of hair cell and support cell differentiation Development, September 15, 2006; 133(18): 3683 - 3693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Brooker, K. Hozumi, and J. Lewis Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear Development, April 1, 2006; 133(7): 1277 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Daudet and J. Lewis Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation Development, February 1, 2005; 132(3): 541 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Hawkins and M. Lovett The developmental genetics of auditory hair cells Hum. Mol. Genet., October 1, 2004; 13(suppl_2): R289 - R296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Inlow and L. L. Restifo Molecular and Comparative Genetics of Mental Retardation Genetics, February 1, 2004; 166(2): 835 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gridley Notch signaling and inherited disease syndromes Hum. Mol. Genet., April 2, 2003; 12(90001): R9 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Chen, J. E. Johnson, H. Y. Zoghbi, and N. Segil The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination Development, March 7, 2003; 129(10): 2495 - 2505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. McCright, J. Lozier, and T. Gridley A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency Development, March 4, 2003; 129(4): 1075 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bryant, R. J Goodyear, and G. P Richardson Sensory organ development in the inner ear: molecular and cellular mechanisms Br. Med. Bull., October 1, 2002; 63(1): 39 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Rivolta, A. Halsall, C. M. Johnson, M. A. Tones, and M. C. Holley Transcript Profiling of Functionally Related Groups of Genes During Conditional Differentiation of a Mammalian Cochlear Hair Cell Line Genome Res., July 1, 2002; 12(7): 1091 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Kiernan, N. Ahituv, H. Fuchs, R. Balling, K. B. Avraham, K. P. Steel, and M. H. de Angelis The Notch ligand Jagged1 is required for inner ear sensory development PNAS, March 16, 2001; (2001) 71496998. [Abstract] [Full Text]
|
|
|
|
|
|
A. E. Kiernan, N. Ahituv, H. Fuchs, R. Balling, K. B. Avraham, K. P. Steel, and M. Hrabe de Angelis The Notch ligand Jagged1 is required for inner ear sensory development PNAS, March 27, 2001; 98(7): 3873 - 3878. [Abstract] [Full Text] [PDF]
|
|