Human Molecular Genetics, 2001, Vol. 10, No. 7 699-703
© 2001 Oxford University Press
The Rb/E2F pathway and cancer
Department of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Over the past decade, studies focusing on the mechanisms controlling cellular proliferation have converged with equally intensive efforts directed at the analysis of oncogenic pathways associated with human cancer. These convergent studies have revealed the central role played by the pathway that controls the activity of the retinoblastoma tumor suppressor protein (Rb), which in turn regulates the E2F transcription factor. In particular, it is now clear that the Rb/E2F pathway is critical in regulating the initiation of DNA replication. It is also clear that the control of the pathway is disrupted in virtually all human cancers. Questions remain, however, as to the specific role played by individual activities within the pathway in the control of cell growth and their participation in the development of cancer.
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|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
K. A. Edgar, M. Belvin, A. L. Parks, K. Whittaker, M. B. Mahoney, M. Nicoll, C. C. Park, C. G. Winter, F. Chen, K. Lickteig, et al. Synthetic Lethality of Retinoblastoma Mutant Cells in the Drosophila Eye by Mutation of a Novel Peptidyl Prolyl Isomerase Gene Genetics, May 1, 2005; 170(1): 161 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Adegbola and G. R. Pasternack Phosphorylated Retinoblastoma Protein Complexes with pp32 and Inhibits pp32-mediated Apoptosis J. Biol. Chem., April 22, 2005; 280(16): 15497 - 15502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
 |
|
 R. M. Douglas, R. Farahani, P. Morcillo, A. Kanaan, T. Xu, and G. G. Haddad Hypoxia induces major effects on cell cycle kinetics and protein expression in Drosophila melanogaster embryos Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R511 - R521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
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J. S. Lipsick synMuv verite--Myb comes into focus Genes & Dev., December 1, 2004; 18(23): 2837 - 2844. [Full Text] [PDF]
|
|
|
|
|
|
P. Dasgupta, J. Sun, S. Wang, G. Fusaro, V. Betts, J. Padmanabhan, S. M. Sebti, and S. P. Chellappan Disruption of the Rb-Raf-1 Interaction Inhibits Tumor Growth and Angiogenesis Mol. Cell. Biol., November 1, 2004; 24(21): 9527 - 9541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Fry, P. J. Harvey, P. R. Keller, W. L. Elliott, M. Meade, E. Trachet, M. Albassam, X. Zheng, W. R. Leopold, N. K. Pryer, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts Mol. Cancer Ther., November 1, 2004; 3(11): 1427 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jiang, H. I. Saavedra, M. P. Holloway, G. Leone, and R. A. Altura Aberrant Regulation of Survivin by the RB/E2F Family of Proteins J. Biol. Chem., September 24, 2004; 279(39): 40511 - 40520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Dasgupta, V. Betts, S. Rastogi, B. Joshi, M. Morris, B. Brennan, D. Ordonez-Ercan, and S. Chellappan Direct Binding of Apoptosis Signal-regulating Kinase 1 to Retinoblastoma Protein: NOVEL LINKS BETWEEN APOPTOTIC SIGNALING AND CELL CYCLE MACHINERY J. Biol. Chem., September 10, 2004; 279(37): 38762 - 38769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kirmizis and P. J. Farnham Genomic Approaches That Aid in the Identification of Transcription Factor Target Genes Experimental Biology and Medicine, September 1, 2004; 229(8): 705 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Wikenheiser-Brokamp Rb family proteins differentially regulate distinct cell lineages during epithelial development Development, September 1, 2004; 131(17): 4299 - 4310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Li, J. Domenico, J. J. Lucas, and E. W. Gelfand Identification of Multiple Cell Cycle Regulatory Functions of p57Kip2 in Human T Lymphocytes J. Immunol., August 15, 2004; 173(4): 2383 - 2391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ianari, R. Gallo, M. Palma, E. Alesse, and A. Gulino Specific Role for p300/CREB-binding Protein-associated Factor Activity in E2F1 Stabilization in Response to DNA Damage J. Biol. Chem., July 16, 2004; 279(29): 30830 - 30835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Gunawardena, H. Siddiqui, D. A. Solomon, C. N. Mayhew, J. Held, S. P. Angus, and E. S. Knudsen Hierarchical Requirement of SWI/SNF in Retinoblastoma Tumor Suppressor-mediated Repression of Plk1 J. Biol. Chem., July 9, 2004; 279(28): 29278 - 29285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Cui, G. Jin, T. Gao, T. Sun, F. Tian, G. G. Estrada, H. Gao, and A. Sarai Characterization of BRCAA1 and Its Novel Antigen Epitope Identification Cancer Epidemiol. Biomarkers Prev., July 1, 2004; 13(7): 1136 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
Y. Zhang and A. W. Hamburger Heregulin Regulates the Ability of the ErbB3-binding Protein Ebp1 to Bind E2F Promoter Elements and Repress E2F-mediated Transcription J. Biol. Chem., June 18, 2004; 279(25): 26126 - 26133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
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|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
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J. M. Roig, M. A. Molina, A. Cascante, J. Calbo, N. Carbo, U. Wirtz, S. Sreedharan, C. Fillat, and A. Mazo Adenovirus-Mediated Retinoblastoma 94 Gene Transfer Induces Human Pancreatic Tumor Regression in a Mouse Xenograft Model Clin. Cancer Res., February 15, 2004; 10(4): 1454 - 1462. [Abstract] [Full Text] [PDF]
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 J. J. Lucas, J. Domenico, and E. W. Gelfand Cyclin-Dependent Kinase 6 Inhibits Proliferation of Human Mammary Epithelial Cells Mol. Cancer Res., February 1, 2004; 2(2): 105 - 114. [Abstract] [Full Text] [PDF]
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C. S. Mitsiades, N. S. Mitsiades, C. J. McMullan, V. Poulaki, R. Shringarpure, T. Hideshima, M. Akiyama, D. Chauhan, N. Munshi, X. Gu, et al. Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications PNAS, January 13, 2004; 101(2): 540 - 545. [Abstract] [Full Text] [PDF]
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S. J. Balsitis, J. Sage, S. Duensing, K. Munger, T. Jacks, and P. F. Lambert Recapitulation of the Effects of the Human Papillomavirus Type 16 E7 Oncogene on Mouse Epithelium by Somatic Rb Deletion and Detection of pRb-Independent Effects of E7 In Vivo Mol. Cell. Biol., December 15, 2003; 23(24): 9094 - 9103. [Abstract] [Full Text] [PDF]
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Z. Yue, S. Jin, C. Yang, A. J. Levine, and N. Heintz Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor PNAS, December 9, 2003; 100(25): 15077 - 15082. [Abstract] [Full Text] [PDF]
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 A Etges, D S Pinto Jr, L P Kowalski, F A Soares, and V C Araujo Salivary duct carcinoma: immunohistochemical profile of an aggressive salivary gland tumour J. Clin. Pathol., December 1, 2003; 56(12): 914 - 918. [Abstract] [Full Text] [PDF]
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G. Fusaro, P. Dasgupta, S. Rastogi, B. Joshi, and S. Chellappan Prohibitin Induces the Transcriptional Activity of p53 and Is Exported from the Nucleus upon Apoptotic Signaling J. Biol. Chem., November 28, 2003; 278(48): 47853 - 47861. [Abstract] [Full Text] [PDF]
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P. Mitra, R.-L. Xie, R. Medina, H. Hovhannisyan, S. K. Zaidi, Y. Wei, J. W. Harper, J. L. Stein, A. J. van Wijnen, and G. S. Stein Identification of HiNF-P, a Key Activator of Cell Cycle-Controlled Histone H4 Genes at the Onset of S Phase Mol. Cell. Biol., November 15, 2003; 23(22): 8110 - 8123. [Abstract] [Full Text] [PDF]
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S. P. Angus, D. A. Solomon, L. Kuschel, R. F. Hennigan, and E. S. Knudsen Retinoblastoma Tumor Suppressor: Analyses of Dynamic Behavior in Living Cells Reveal Multiple Modes of Regulation Mol. Cell. Biol., November 15, 2003; 23(22): 8172 - 8188. [Abstract] [Full Text] [PDF]
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F. Zindy, L. M. Nilsson, L. Nguyen, C. Meunier, R. J. Smeyne, J. E. Rehg, C. Eberhart, C. J. Sherr, and M. F. Roussel Hemangiosarcomas, Medulloblastomas, and Other Tumors in Ink4c/p53-null Mice Cancer Res., September 1, 2003; 63(17): 5420 - 5427. [Abstract] [Full Text] [PDF]
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A. Chakravarti, K. Heydon, C.L. Wu, E. Hammond, A. Pollack, M. Roach, H. Wolkov, P. Okunieff, J. Cox, J. Fontanesi, et al. Loss of p16 Expression Is of Prognostic Significance in Locally Advanced Prostate Cancer: An Analysis From the Radiation Therapy Oncology Group Protocol 86-10 J. Clin. Oncol., September 1, 2003; 21(17): 3328 - 3334. [Abstract] [Full Text] [PDF]
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G. Fingerle-Rowson, O. Petrenko, C. N. Metz, T. G. Forsthuber, R. Mitchell, R. Huss, U. Moll, W. Muller, and R. Bucala The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting PNAS, August 5, 2003; 100(16): 9354 - 9359. [Abstract] [Full Text] [PDF]
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N. Ohtani, P. Brennan, S. Gaubatz, E. Sanij, P. Hertzog, E. Wolvetang, J. Ghysdael, M. Rowe, and E. Hara Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5 J. Cell Biol., July 21, 2003; 162(2): 173 - 183. [Abstract] [Full Text] [PDF]
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D. S. Fay, E. Large, M. Han, and M. Darland lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans Development, July 15, 2003; 130(14): 3319 - 3330. [Abstract] [Full Text] [PDF]
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S. Paternot, K. Coulonval, J. E. Dumont, and P. P. Roger Cyclic AMP-dependent Phosphorylation of Cyclin D3-bound CDK4 Determines the Passage through the Cell Cycle Restriction Point in Thyroid Epithelial Cells J. Biol. Chem., July 11, 2003; 278(29): 26533 - 26540. [Abstract] [Full Text] [PDF]
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A. de Bruin, L. Wu, H. I. Saavedra, P. Wilson, Y. Yang, T. J. Rosol, M. Weinstein, M. L. Robinson, and G. Leone Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice PNAS, May 27, 2003; 100(11): 6546 - 6551. [Abstract] [Full Text] [PDF]
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Y. Ma, J. Yuan, M. Huang, R. Jove, and W. D. Cress Regulation of the Cyclin D3 Promoter by E2F1 J. Biol. Chem., May 2, 2003; 278(19): 16770 - 16776. [Abstract] [Full Text] [PDF]
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S. Jirawatnotai, D. S. Moons, C. O. Stocco, R. Franks, D. B. Hales, G. Gibori, and H. Kiyokawa The Cyclin-dependent Kinase Inhibitors p27Kip1 and p21Cip1 Cooperate to Restrict Proliferative Life Span in Differentiating Ovarian Cells J. Biol. Chem., May 2, 2003; 278(19): 17021 - 17027. [Abstract] [Full Text] [PDF]
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 R. Elkon, C. Linhart, R. Sharan, R. Shamir, and Y. Shiloh Genome-Wide In Silico Identification of Transcriptional Regulators Controlling the Cell Cycle in Human Cells Genome Res., May 1, 2003; 13(5): 773 - 780. [Abstract] [Full Text] [PDF]
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G. Gao, A. P. Bracken, K. Burkard, D. Pasini, M. Classon, C. Attwooll, M. Sagara, T. Imai, K. Helin, and J. Zhao NPAT Expression Is Regulated by E2F and Is Essential for Cell Cycle Progression Mol. Cell. Biol., April 15, 2003; 23(8): 2821 - 2833. [Abstract] [Full Text] [PDF]
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O. Petrenko, G. Fingerle-Rowson, T. Peng, R. A. Mitchell, and C. N. Metz Macrophage Migration Inhibitory Factor Deficiency Is Associated with Altered Cell Growth and Reduced Susceptibility to Ras-mediated Transformation J. Biol. Chem., March 21, 2003; 278(13): 11078 - 11085. [Abstract] [Full Text] [PDF]
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A. B. Gladden and J. A. Diehl The Cyclin D1-dependent Kinase Associates with the Pre-replication Complex and Modulates RB{middle dot}MCM7 Binding J. Biol. Chem., March 7, 2003; 278(11): 9754 - 9760. [Abstract] [Full Text] [PDF]
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 A. Ryo, Y.-C. Liou, K. P. Lu, and G. Wulf Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer J. Cell Sci., March 1, 2003; 116(5): 773 - 783. [Abstract] [Full Text] [PDF]
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 R. Danesi, F. De Braud, S. Fogli, T. M. De Pas, A. Di Paolo, G. Curigliano, and M. Del Tacca Pharmacogenetics of Anticancer Drug Sensitivity in Non-Small Cell Lung Cancer Pharmacol. Rev., March 1, 2003; 55(1): 57 - 103. [Abstract] [Full Text] [PDF]
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A. Kirmizis, S. M. Bartley, and P. J. Farnham Identification of the Polycomb Group Protein SU(Z)12 as a Potential Molecular Target for Human Cancer Therapy Mol. Cancer Ther., January 1, 2003; 2(1): 113 - 121. [Abstract] [Full Text] [PDF]
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C. Lee, J. H. Chang, H. S. Lee, and Y. Cho Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor Genes & Dev., December 15, 2002; 16(24): 3199 - 3212. [Abstract] [Full Text] [PDF]
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X. Zou, D. Ray, A. Aziyu, K. Christov, A. D. Boiko, A. V. Gudkov, and H. Kiyokawa Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence Genes & Dev., November 15, 2002; 16(22): 2923 - 2934. [Abstract] [Full Text] [PDF]
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M. D. Apostolova, I. A. Ivanova, C. Dagnino, S. J. A. D'Souza, and L. Dagnino Active Nuclear Import and Export Pathways Regulate E2F-5 Subcellular Localization J. Biol. Chem., September 6, 2002; 277(37): 34471 - 34479. [Abstract] [Full Text] [PDF]
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