Human Molecular Genetics, 2001, Vol. 10, No. 7 721-733
© 2001 Oxford University Press
The ABC of APC
1Cancer and Immunogenetics Laboratory, Imperial Cancer Research Fund, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK and 2Department of Colorectal Surgery, John Radcliffe Hospital, Oxford OX3 9DU, UK
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease characterized by the presence of adenomatous polyps in the colon and rectum, with inevitable development of colorectal cancer if left untreated. FAP is caused by germline mutations in the adenomatous polyposis coli (APC) gene. Somatic mutations in the APC gene are an early event in colorectal tumorigenesis, and can be detected in the majority of colorectal tumours. The APC gene encodes a large protein with multiple cellular functions and interactions, including roles in signal transduction in the wnt-signalling pathway, mediation of intercellular adhesion, stabilization of the cytoskeleton and possibly regulation of the cell cycle and apoptosis. The fact that APC is an integral part of so many different pathways makes it an ideal target for mutation in carcinogenesis. This review deals with our understanding to date of how mutations in the APC gene translate into changes at the protein level, which in turn contribute to the role of APC in tumorigenesis.
+ To whom correspondence should be addressed. Tel: +44 1865 222356; Fax: +44 1865 222384; Email: walter.bodmer@hertford.ox.ac.uk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. C. Kim, F. M. Barlaskar, J. H. Heaton, T. Else, V. R. Kelly, K. T. Krill, J. O. Scheys, D. P. Simon, A. Trovato, W.-H. Yang, et al. In Search of Adrenocortical Stem and Progenitor Cells Endocr. Rev., May 1, 2009; 30(3): 241 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kaufmann, S. Vogt, S. Uhlhaas, D. Stienen, I. Kurth, H. Hameister, E. Mangold, J. Kotting, E. Kaminsky, P. Propping, et al. Analysis of Rare APC Variants at the mRNA Level: Six Pathogenic Mutations and Literature Review J. Mol. Diagn., March 1, 2009; 11(2): 131 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. D. Foulkes Inherited Susceptibility to Common Cancers N. Engl. J. Med., November 13, 2008; 359(20): 2143 - 2153. [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Groen, A. Roos, F. L. Muntinghe, R. H. Enting, J. de Vries, J. H. Kleibeuker, M. J. H. Witjes, T. P. Links, and A. P. van Beek Extra-Intestinal Manifestations of Familial Adenomatous Polyposis Ann. Surg. Oncol., September 1, 2008; 15(9): 2439 - 2450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A R Dallosso, S Dolwani, N Jones, S Jones, J Colley, J Maynard, S Idziaszczyk, V Humphreys, J Arnold, A Donaldson, et al. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3 Gut, September 1, 2008; 57(9): 1252 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Kohler, A. Derungs, G. Daum, J. Behrens, and J. Schneikert Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours Hum. Mol. Genet., July 1, 2008; 17(13): 1978 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Bodmer and L. A. Loeb Genetic Instability Is Not a Requirement for Tumor Development Cancer Res., May 15, 2008; 68(10): 3558 - 3561. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Suehiro, C. W. Wong, L. R. Chirieac, Y. Kondo, L. Shen, C. R. Webb, Y. W. Chan, A. S.Y. Chan, T. L. Chan, T.-T. Wu, et al. Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and P53 Pathways in Colorectal Carcinoma Clin. Cancer Res., May 1, 2008; 14(9): 2560 - 2569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Brocardo, Y. Lei, A. Tighe, S. S. Taylor, M. T. S. Mok, and B. R. Henderson Mitochondrial Targeting of Adenomatous Polyposis Coli Protein Is Stimulated by Truncating Cancer Mutations: REGULATION OF Bcl-2 AND IMPLICATIONS FOR CELL SURVIVAL J. Biol. Chem., February 29, 2008; 283(9): 5950 - 5959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Azzopardi, A. R. Dallosso, K. Eliason, B. C. Hendrickson, N. Jones, E. Rawstorne, J. Colley, V. Moskvina, C. Frye, J. R. Sampson, et al. Multiple Rare Nonsynonymous Variants in the Adenomatous Polyposis Coli Gene Predispose to Colorectal Adenomas Cancer Res., January 15, 2008; 68(2): 358 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F J Hes, M Nielsen, E C Bik, D Konvalinka, J T Wijnen, E Bakker, H F A Vasen, M H Breuning, and C M J Tops Somatic APC mosaicism: an underestimated cause of polyposis coli Gut, January 1, 2008; 57(1): 71 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Uronis, H. H. Herfarth, T. C. Rubinas, A. C. Bissahoyo, K. Hanlon, and D. W. Threadgill Flat Colorectal Cancers Are Genetically Determined and Progress to Invasion without Going through a Polypoid Stage Cancer Res., December 15, 2007; 67(24): 11594 - 11600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. N. Kundu, R. Balusu, A. S. Jaiswal, and S. Narayan Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways Carcinogenesis, October 1, 2007; 28(10): 2089 - 2095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Caldwell, R. A. Green, and K. B. Kaplan APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice J. Cell Biol., September 24, 2007; 178(7): 1109 - 1120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Suraweera, A. Latchford, A. McCart, P. Rogers, S. Spain, O. Sieber, R. Phillips, I. Tomlinson, and A. Silver Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP J. Med. Genet., August 1, 2007; 44(8): 541 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. N. Kwong, A. Shedlovsky, B. S. Biehl, L. Clipson, C. A. Pasch, and W. F. Dove Identification of Mom7, a Novel Modifier of ApcMin/+ on Mouse Chromosome 18 Genetics, June 1, 2007; 176(2): 1237 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Baran, K. A. Silverman, J. Zeskand, R. Koratkar, A. Palmer, K. McCullen, W. J. Curran Jr, T. B. Edmonston, L. D. Siracusa, and A. M. Buchberg The modifier of Min 2 (Mom2) locus: Embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression Genome Res., May 1, 2007; 17(5): 566 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schneikert and J. Behrens The canonical Wnt signalling pathway and its APC partner in colon cancer development Gut, March 1, 2007; 56(3): 417 - 425. [Full Text] [PDF]
|
|
|
|
|
|
M. Idogawa, M. Masutani, M. Shitashige, K. Honda, T. Tokino, Y. Shinomura, K. Imai, S. Hirohashi, and T. Yamada Ku70 and Poly(ADP-Ribose) Polymerase-1 Competitively Regulate {beta}-Catenin and T-Cell Factor-4-Mediated Gene Transactivation: Possible Linkage of DNA Damage Recognition and Wnt Signaling Cancer Res., February 1, 2007; 67(3): 911 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pagenstecher, D. Gadzicki, D. Stienen, S. Uhlhaas, E. Mangold, N. Rahner, M. Arslan-Kirchner, P. Propping, W. Friedl, and S. Aretz A Complex Rearrangement in the APC Gene Uncovered by Multiplex Ligation-Dependent Probe Amplification J. Mol. Diagn., February 1, 2007; 9(1): 122 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Femia, P. Dolara, A. Giannini, M. Salvadori, A. Biggeri, and G. Caderni Frequent Mutation of Apc Gene in Rat Colon Tumors and Mucin-Depleted Foci, Preneoplastic Lesions in Experimental Colon Carcinogenesis Cancer Res., January 15, 2007; 67(2): 445 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schneikert, A. Grohmann, and J. Behrens Truncated APC regulates the transcriptional activity of {beta}-catenin in a cell cycle dependent manner Hum. Mol. Genet., January 15, 2007; 16(2): 199 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Sodir, X. Chen, R. Park, A. E. Nickel, P. S. Conti, R. Moats, J. R. Bading, D. Shibata, and P. W. Laird Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ Mice. Cancer Res., September 1, 2006; 66(17): 8430 - 8438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Park, J. Gwak, M. Cho, T. Song, J. Won, D.-E. Kim, J.-G. Shin, and S. Oh Hexachlorophene Inhibits Wnt/beta-Catenin Pathway by Promoting Siah-Mediated beta-Catenin Degradation Mol. Pharmacol., September 1, 2006; 70(3): 960 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Fenton and N. G. Hord Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research Carcinogenesis, May 1, 2006; 27(5): 893 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-S. Park, S. H. Jeon, S.-E. Kim, Y.-Y. Bahk, S. L. Holmen, B. O. Williams, K.-C. Chung, Y.-J. Surh, and K.-Y. Choi APC inhibits ERK pathway activation and cellular proliferation induced by RAS J. Cell Sci., March 1, 2006; 119(5): 819 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Singh, J. N. Artaza, W. E. Taylor, M. Braga, X. Yuan, N. F. Gonzalez-Cadavid, and S. Bhasin Testosterone Inhibits Adipogenic Differentiation in 3T3-L1 Cells: Nuclear Translocation of Androgen Receptor Complex with {beta}-Catenin and T-Cell Factor 4 May Bypass Canonical Wnt Signaling to Down-Regulate Adipogenic Transcription Factors Endocrinology, January 1, 2006; 147(1): 141 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Ellison, O. E. Onilude, J. C. Lindsey, M. E. Lusher, C. L. Weston, R. E. Taylor, A. D. Pearson, and S. C. Clifford {beta}-Catenin Status Predicts a Favorable Outcome in Childhood Medulloblastoma: The United Kingdom Children's Cancer Study Group Brain Tumour Committee J. Clin. Oncol., November 1, 2005; 23(31): 7951 - 7957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Green, R. Wollman, and K. B. Kaplan APC and EB1 Function Together in Mitosis to Regulate Spindle Dynamics and Chromosome Alignment Mol. Biol. Cell, October 1, 2005; 16(10): 4609 - 4622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Frattini, I. Carnevali, S. Signoroni, D. Balestra, M. L. Moiraghi, P. Radice, L. Varesco, V. Gismondi, G. Ballardini, P. Sala, et al. Cyclooxygenase-2 Expression in FAP Patients Carrying Germ Line MYH Mutations Cancer Epidemiol. Biomarkers Prev., August 1, 2005; 14(8): 2049 - 2052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. V. Rao, Y.-M. Yang, M. V. Swamy, T. Liu, Y. Fang, R. Mahmood, M. Jhanwar-Uniyal, and W. Dai Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability PNAS, March 22, 2005; 102(12): 4365 - 4370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-N. Qian, J. Knol, P. Igarashi, F. Lin, U. Zylstra, B. T. Teh, and B. O. Williams Cystic Renal Neoplasia Following Conditional Inactivation of Apc in Mouse Renal Tubular Epithelium J. Biol. Chem., February 4, 2005; 280(5): 3938 - 3945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, C. Rocken, C. Lofton-Day, H.-U. Schulz, O. Muller, N. Kutzner, P. Malfertheiner, and M. P.A. Ebert Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis Carcinogenesis, January 1, 2005; 26(1): 37 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. M. Sieber, K. M. Howarth, C. Thirlwell, A. Rowan, N. Mandir, R. A. Goodlad, A. Gilkar, B. Spencer-Dene, G. Stamp, V. Johnson, et al. Myh Deficiency Enhances Intestinal Tumorigenesis in Multiple Intestinal Neoplasia (ApcMin/+) Mice Cancer Res., December 15, 2004; 64(24): 8876 - 8881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tighe, V. L. Johnson, and S. S. Taylor Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability J. Cell Sci., December 15, 2004; 117(26): 6339 - 6353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Choi, S. Y. Park, F. Costantini, E.-h. Jho, and C.-K. Joo Adenomatous Polyposis Coli Is Down-regulated by the Ubiquitin-Proteasome Pathway in a Process Facilitated by Axin J. Biol. Chem., November 19, 2004; 279(47): 49188 - 49198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Fearnhead, J. L. Wilding, B. Winney, S. Tonks, S. Bartlett, D. C. Bicknell, I. P. M. Tomlinson, N. J. McC. Mortensen, and W. F. Bodmer Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas PNAS, November 9, 2004; 101(45): 15992 - 15997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Li and R. H. Dashwood Activator Protein 2{alpha} Associates with Adenomatous Polyposis Coli/{beta}-Catenin and Inhibits {beta}-Catenin/T-cell Factor Transcriptional Activity in Colorectal Cancer Cells J. Biol. Chem., October 29, 2004; 279(44): 45669 - 45675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-J. Guo, E. Huang, T. Ezaki, N. Patel, K. Sinclair, J. Wu, P. Klein, E.-R. Suh, and J. P. Lynch Cdx1 Inhibits Human Colon Cancer Cell Proliferation by Reducing {beta}-Catenin/T-cell Factor Transcriptional Activity J. Biol. Chem., August 27, 2004; 279(35): 36865 - 36875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Temburni, M. M. Rosenberg, N. Pathak, R. McConnell, and M. H. Jacob Neuronal Nicotinic Synapse Assembly Requires the Adenomatous Polyposis Coli Tumor Suppressor Protein J. Neurosci., July 28, 2004; 24(30): 6776 - 6784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Luchtenborg, M. P. Weijenberg, G. M. J. M. Roemen, A. P. de Bruine, P. A. van den Brandt, M. H. F. M. Lentjes, M. Brink, M. van Engeland, R. A. Goldbohm, and A. F. P. M. de Goeij APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study Carcinogenesis, July 1, 2004; 25(7): 1219 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Valle, R. Rodriguez-Lopez, M. Robledo, J. Benitez, and M. Urioste Concurrence of Germline Mutations in the APC and PTEN Genes in a Colonic Polyposis Family Member J. Clin. Oncol., June 1, 2004; 22(11): 2252 - 2253. [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Muller, L. Ivarsson, H. Schrocksnadel, H. Fiegl, A. Widschwendter, G. Goebel, S. Kilga-Nogler, H. Philadelphy, W. Gutter, C. Marth, et al. DNA Methylation Changes in Sera of Women in Early Pregnancy Are Similar to Those in Advanced Breast Cancer Patients Clin. Chem., June 1, 2004; 50(6): 1065 - 1068. [Full Text] [PDF]
|
|
|
|
|
|
D. Dikovskaya, I. P. Newton, and I. S. Nathke The Adenomatous Polyposis Coli Protein Is Required for the Formation of Robust Spindles Formed in CSF Xenopus Extracts Mol. Biol. Cell, June 1, 2004; 15(6): 2978 - 2991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-M. Kim, P. Calabrese, S. Tavare, and D. Shibata Enhanced Stem Cell Survival in Familial Adenomatous Polyposis Am. J. Pathol., April 1, 2004; 164(4): 1369 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sekiya, S. Adachi, K. Kohu, T. Yamada, O. Higuchi, Y. Furukawa, Y. Nakamura, T. Nakamura, K. Tashiro, S. Kuhara, et al. Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor-{beta} Signaling, as a Target of the {beta}-Catenin Pathway in Colorectal Tumor Cells J. Biol. Chem., February 20, 2004; 279(8): 6840 - 6846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M L Bisgaard, R Ripa, A L Knudsen, and S Bulow Familial adenomatous polyposis patients without an identified APC germline mutation have a severe phenotype Gut, February 1, 2004; 53(2): 266 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M D Crabtree, C Fletcher, M Churchman, S V Hodgson, K Neale, R K S Phillips, and I P M Tomlinson Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases Gut, February 1, 2004; 53(2): 271 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. BIRD and D. MACLEOD Reading the DNA Methylation Signal Cold Spring Harb Symp Quant Biol, January 1, 2004; 69(0): 113 - 118. [Abstract] [PDF]
|
|
|
|
|
|
H. Yamada, K. Furuuchi, T. Aoyama, A. Kataoka, J.-i. Hamada, M. Tada, S. Okushiba, S. Kondo, T. Moriuchi, and H. Katoh Reconstructed {beta}-Catenin/TCF4 Signaling in Yeast Applicable to Functional Evaluation of APC Mutations Am. J. Pathol., December 1, 2003; 163(6): 2201 - 2209. [Abstract] [Full Text]
|
|
|
|
|
|
H. M. Muller, A. Widschwendter, H. Fiegl, L. Ivarsson, G. Goebel, E. Perkmann, C. Marth, and M. Widschwendter DNA Methylation in Serum of Breast Cancer Patients: An Independent Prognostic Marker Cancer Res., November 15, 2003; 63(22): 7641 - 7645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Cheadle and J. R. Sampson Exposing the MYtH about base excision repair and human inherited disease Hum. Mol. Genet., October 15, 2003; 12(90002): R159 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lee, H. L. Miller, P. Jensen, R. Hernan, M. Connelly, C. Wetmore, F. Zindy, M. F. Roussel, T. Curran, R. J. Gilbertson, et al. A Molecular Fingerprint for Medulloblastoma Cancer Res., September 1, 2003; 63(17): 5428 - 5437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bertario, A. Russo, P. Sala, L. Varesco, M. Giarola, P. Mondini, M. Pierotti, P. Spinelli, and P. Radice Multiple Approach to the Exploration of Genotype-Phenotype Correlations in Familial Adenomatous Polyposis J. Clin. Oncol., May 1, 2003; 21(9): 1698 - 1707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Ferenci How to identify the genetic basis of gastrointestinal and liver diseases? Gut, May 1, 2003; 52(90002): ii6 - 9. [Abstract] [Full Text]
|
|
|
|
|
|
O. M. Sieber, K. Heinimann, P. Gorman, H. Lamlum, M. Crabtree, C. A. Simpson, D. Davies, K. Neale, S. V. Hodgson, R. R. Roylance, et al. Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC PNAS, December 24, 2002; 99(26): 16910 - 16915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S Fearnhead, J. L Wilding, and W. F Bodmer Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis Br. Med. Bull., December 1, 2002; 64(1): 27 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Guttmacher and F. S. Collins Genomic Medicine -- A Primer N. Engl. J. Med., November 7, 2002; 347(19): 1512 - 1520. [Full Text] [PDF]
|
|
|
|
|
|
S. Jones, P. Emmerson, J. Maynard, J. M. Best, S. Jordan, G. T. Williams, J. R. Sampson, and J. P. Cheadle Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C->T:A mutations Hum. Mol. Genet., November 1, 2002; 11(23): 2961 - 2967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Lamprecht and M. Lipkin Migrating colonic crypt epithelial cells: primary targets for transformation Carcinogenesis, November 1, 2002; 23(11): 1777 - 1780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Povey, A. F. Badawi, D. P. Cooper, C. N. Hall, K. L. Harrison, P. E. Jackson, N. P. Lees, P. J. O'Connor, and G. P. Margison DNA Alkylation and Repair in the Large Bowel: Animal and Human Studies J. Nutr., November 1, 2002; 132(11): 3518S - 3521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Koratkar, E. Pequignot, W. W. Hauck, and L. D. Siracusa The CAST/Ei Strain Confers Significant Protection against ApcMin Intestinal Polyps, Independent of the Resistant Modifier of Min 1 (Mom1R) Locus Cancer Res., October 1, 2002; 62(19): 5413 - 5417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tickenbrock, J. Cramer, I. R. Vetter, and O. Muller The Coiled Coil Region (Amino Acids 129-250) of the Tumor Suppressor Protein Adenomatous Polyposis Coli (APC). ITS STRUCTURE AND ITS INTERACTION WITH CHROMOSOME MAINTENANCE REGION 1 (Crm-1) J. Biol. Chem., August 23, 2002; 277(35): 32332 - 32338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Karbova, B. Davidson, K. Metodiev, C. G. Trope, and J. M. Nesland Adenomatous Polyposis Coli (APC) Protein Expression in Primary and Metastatic Serous Ovarian Carcinoma International Journal of Surgical Pathology, July 1, 2002; 10(3): 175 - 180. [Abstract] [PDF]
|
|
|
|
|
|
M. Zysman, A. Saka, A. Millar, J. Knight, W. Chapman, and B. Bapat Methylation of Adenomatous Polyposis Coli in Endometrial Cancer Occurs More Frequently in Tumors with Microsatellite Instability Phenotype Cancer Res., July 1, 2002; 62(13): 3663 - 3666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Anderson, K. L. Neufeld, and R. L. White Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon PNAS, June 25, 2002; 99(13): 8683 - 8688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sekiya, T. Nakamura, Y. Kazuki, M. Oshimura, K. Kohu, K.-i. Tago, S. Ohwada, and T. Akiyama Overexpression of Icat Induces G2 Arrest and Cell Death in Tumor Cell Mutants for Adenomatous Polyposis Coli, {beta}-catenin, or Axin Cancer Res., June 1, 2002; 62(11): 3322 - 3326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Amit, A. Hatzubai, Y. Birman, J. S. Andersen, E. Ben-Shushan, M. Mann, Y. Ben-Neriah, and I. Alkalay Axin-mediated CKI phosphorylation of beta -catenin at Ser 45: a molecular switch for the Wnt pathway Genes & Dev., May 1, 2002; 16(9): 1066 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Eads, A. E. Nickel, and P. W. Laird Complete Genetic Suppression of Polyp Formation and Reduction of CpG-Island Hypermethylation in ApcMin/+Dnmt1-Hypomorphic Mice Cancer Res., March 1, 2002; 62(5): 1296 - 1299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.L. Stanton and D.P.L. Green A set of 1542 mouse blastocyst and pre-blastocyst genes with well-matched human homologues Mol. Hum. Reprod., February 1, 2002; 8(2): 149 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ahmed, A. Nouri, and E. Wieschaus Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development Development, January 4, 2002; 129(7): 1751 - 1762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, L. A. Hu, M. V. Semenov, S. Yanagawa, A. Kikuchi, R. J. Lefkowitz, and W. E. Miller beta -Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins PNAS, December 6, 2001; (2001) 211572798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Esteller, M. F. Fraga, M. Guo, J. Garcia-Foncillas, I. Hedenfalk, A. K. Godwin, J. Trojan, C. Vaurs-Barriere, Y.-J. Bignon, S. Ramus, et al. DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis Hum. Mol. Genet., December 1, 2001; 10(26): 3001 - 3007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, L. A. Hu, M. V. Semenov, S. Yanagawa, A. Kikuchi, R. J. Lefkowitz, and W. E. Miller beta -Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins PNAS, December 18, 2001; 98(26): 14889 - 14894. [Abstract] [Full Text] [PDF]
|
|