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Human Molecular Genetics, 2002, Vol. 11, No. 10 1185-1193
© 2002 Oxford University Press

Anterior segment dysgenesis and the developmental glaucomas are complex traits

Douglas B. Gould and Simon W. M. John*

The Howard Hughes Medical Institute and The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA

Received February 19, 2002; Accepted March 19, 2002

Glaucoma refers to a heterogeneous group of disorders that involve retinal ganglion cell death, optic nerve damage, and loss of visual field. Glaucoma is a leading cause of vision loss worldwide, affecting an estimated 67 million people. Elevated intraocular pressure is a major risk factor for glaucoma. Individuals with malformations of structures of the anterior segment of the eye frequently develop elevated intraocular pressure and glaucoma. In this review, we focus on the developmental glaucomas, the subset of glaucomas associated with anterior segment dysgenesis. To minimize overlap with other reviews in this issue and elsewhere, we highlight the complex, multifactorial nature of these diseases and recent advances using mice.

* To whom correspondence should be addressed: Tel: +1 207 288 6496; Fax: +1 207 288 6079; Email: swmj{at}jax.org


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