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Human Molecular Genetics, 2002, Vol. 11, No. 20 2507-2515
© 2002 Oxford University Press

Gene finding in genetically isolated populations

Peter Heutink* and Ben A. Oostra

Institute of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands

Received July 3, 2002; Accepted July 17, 2002

The struggle to identify susceptibility genes for complex disorders has stimulated geneticists to develop new approaches. One approach that has gained considerable interest is to focus on genetically isolated populations rather than on the general population. There remains much controversy and theoretical debate over the feasibility and advantages of such populations, but recent results speak in favor of the feasibility of this approach, and will be reviewed here.

* To whom correspondence should be addressed at: Department of Clinical Genetics, Erasmus MC Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands. Tel: +31 104088136; Fax: +31 104089384; Email: heutink{at}kgen.fgg.eur.nl


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