Human Molecular Genetics, 2002, Vol. 11, No. 5 569-576
© 2002 Oxford University Press
The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
University of British Columbia McDonald Research Laboratories/iCAPTURE Center, St Paul’s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada, 1Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA and 2Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada
The matrix metalloproteinases (MMPs) comprise a family of at least 20 proteolytic enzymes that play an essential role in tissue remodeling. MMP1 (interstitial collagenase), MMP9 (gelatinase B) and MMP12 (macrophage elastase) are thought to be important in the development of emphysema. A number of naturally occurring polymorphisms of human MMP gene promoters have been identified and found to alter transcriptional activity. Additionally, we detected a novel polymorphism in the MMP12 coding region (Asn357Ser). The aim of this study was to investigate the role of MMP polymorphisms in the development of chronic obstructive lung disease. We determined the prevalence of these polymorphisms in 590 continuing smokers chosen from the National Heart Lung and Blood Institute, Lung Health Study for having the fastest (n = 284) and slowest (n = 306) 5 year rate of decline of lung function. Of the five polymorphisms, only G–1607GG was associated with a rate of decline in lung function. The –1607GG allele was negatively associated with a fast rate of decline (P = 0.02). However, haplotypes consisting of alleles from the MMP1 G–1607GG and MMP12 Asn357Ser polymorphisms were associated with rate of decline of lung function (P = 0.0007). These data suggest that polymorphisms in the MMP1 and MMP12 genes, but not MMP9, are either causative factors in smoking-related lung injury or are in linkage disequilibrium with causative polymorphisms.
+ To whom correspondence should be addressed. Tel: +1 604 806 9008; Fax: +1 604 806 8351; Email: asandford@mrl.ubc.ca
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