Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (72)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Devlin, B.
Right arrow Articles by Kaye, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Devlin, B.
Right arrow Articles by Kaye, W. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, 2002, Vol. 11, No. 6 689-696
© 2002 Oxford University Press

Linkage analysis of anorexia nervosa incorporating behavioral covariates

Bernie Devlin1,+, Silviu-Alin Bacanu1, Kelly L. Klump2, Cynthia M. Bulik3, Manfred M. Fichter4, Katherine A. Halmi5, Allan S. Kaplan6,7, Michael Strober8, Janet Treasure9, D. Blake Woodside7, Wade H. Berrettini10 and Walter H. Kaye1

1Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213-2593, USA, 2Department of Psychology, Michigan State University, East Lansing, MI, 48824, USA, 3Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA 23298-0126, USA, 4Klinik Roseneck, Hospital for Behavioral Medicine, affiliated with the University of Munich, Prien, Germany, 5New York Presbyterian Hospital, Weill Medical College of Cornell University, White Plains, NY 10605, USA, 6Program for Eating Disorders and 7Department of Psychiatry, Toronto General Hospital, Toronto, Ontario, M5G 2C4, Canada, 8Department of Psychiatry and Behavioral Science, University of California at Los Angeles, Los Angeles, CA 90024-1759, USA, 9Eating Disorders Unit, Institute of Psychiatry and South London and Maudsley National Health Service Trust, UK and 10Center of Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA

Eating disorders, such as anorexia nervosa (AN) and bulimia nervosa (BN), have genetic and environmental underpinnings. To explore genetic contributions to AN, we measured psychiatric, personality and temperament phenotypes of individuals diagnosed with eating disorders from 196 multiplex families, all accessed through an AN proband, as well as genotyping a battery of 387 short tandem repeat (STR) markers distributed across the genome. On these data we performed a multipoint affected sibling pair (ASP) linkage analysis using a novel method that incorporates covariates. By exploring seven attributes thought to typify individuals with eating disorders, we identified two variables, drive-for-thinness and obsessionality, which delimit populations among the ASPs. For both of these traits, or covariates, there were a cluster of ASPs who have high and concordant values for these traits, in keeping with our expectations for individuals with AN, and other clusters of ASPs who did not meet those expectations. When we incorporated these covariates into the ASP linkage analysis, both jointly and separately, we found several regions of suggestive linkage: one close to genome-wide significance on chromosome 1 (at 210 cM, D1S1660; LOD = 3.46, P = 0.00003), another on chromosome 2 (at 114 cM, D2S1790; LOD = 2.22, P = 0.00070) and a third region on chromosome 13 (at 26 cM, D13S894; LOD = 2.50, P = 0.00035). By comparing our results to those implemented using more standard linkage methods, we find the covariates convey substantial information for the linkage analysis.

+ To whom correspondence should be addressed. Tel: +1 412 624 1432; Fax: +1 412 624 8181; Email: devlinbj@msx.upmc.edu


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Psychosom. Med.Home page
J. D. Flory and S. B. Manuck
Impulsiveness and Cigarette Smoking
Psychosom Med, May 1, 2009; 71(4): 431 - 437.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Fujimoto, T. Shiuchi, T. Miki, Y. Minokoshi, Y. Takahashi, A. Takeuchi, K. Kimura, M. Saito, T. Iwanaga, and S. Seino
Dmbx1 is essential in agouti-related protein action
PNAS, September 25, 2007; 104(39): 15514 - 15519.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
R. Abou Jamra, C. Schmael, S. Cichon, M. Rietschel, J. Schumacher, and M. M. Nothen
Genes and Schizophrenia: The G72/G30 Gene Locus in Psychiatric Disorders: A Challenge to Diagnostic Boundaries?
Schizophr Bull, October 1, 2006; 32(4): 599 - 608.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
D. A. Collier and J. L. Treasure
The aetiology of eating disorders
The British Journal of Psychiatry, November 1, 2004; 185(5): 363 - 365.
[Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
P. K. Keel, M. Fichter, N. Quadflieg, C. M. Bulik, M. G. Baxter, L. Thornton, K. A. Halmi, A. S. Kaplan, M. Strober, D. B. Woodside, et al.
Application of a Latent Class Analysis to Empirically Define Eating Disorder Phenotypes
Arch Gen Psychiatry, February 1, 2004; 61(2): 192 - 200.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.