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Human Molecular Genetics, 2003, Vol. 12, No. 11 1273-1277
DOI: 10.1093/hmg/ddg135
© 2003 Oxford University Press

Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p

Maolian Gong1,2, Hongye Zhang1, Herbert Schulz2,3, Young-Ae Lee2,4, Kai Sun1, Sylvia Bähring2,5, Friedrich C. Luft2,5, Peter Nürnberg2,6, André Reis2,7, Klaus Rohde2, Detlev Ganten2,3, Rutai Hui1 and Norbert Hübner2,3,*

1Cardiovascular Institute, Sino-German Laboratory, FuWai Hospital, Beijing, People's Republic of China, 2Max-Delbrück-Center for Molecular Medicine (MDC), Berlin-Buch, Germany, 3Department of Clinical Pharmacology, Freie University, Berlin, Germany, 4Department of Pediatric Pneumology and Immunology, Charité, Humboldt-University Berlin, Germany, 5Franz Volhard Clinic, HELIOS-Klinikum, Charité, Humboldt-University Berlin, Germany, 6Institute of Medical Genetics, Charité, Humboldt-University Berlin, Germany and 7Department of Human Genetics, Friedrich-Alexander University, Erlangen, Germany

Received January 13, 2003; Revised March 4, 2003; Accepted March 21, 2003

Essential (primary) hypertension is an important risk factor for cardiovascular morbidity and mortality. Blood pressure is largely heritable; however, the genetic factors contributing to essential hypertension are mostly unknown. We examined a large Chinese kindred (n=387) and selected a subset of 94 individuals for genotyping. An additional 32 Chinese nuclear families with essential hypertension were also recruited. Genome-wide parametric linkage analysis identified a new locus for primary hypertension on chromosome 12p (parametric LOD score 3.44). This locus overlaps with the assigned locus that causes severe autosomal-dominant hypertension and brachydactyly, the only form of monogenic hypertension known to date that resembles primary hypertension. We suggest that this genomic region, spanning 18 annotated genes, will be of great relevance in elucidating new mechanisms for primary hypertension.

* To whom correspondence should be addressed at: Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13092 Berlin, Germany. Tel: +49 3094062530; Fax: +49 3094062110; Email: nhuebner{at}mdc-berlin.de


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