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Human Molecular Genetics, 2003, Vol. 12, No. 12 1361-1365
DOI: 10.1093/hmg/ddg149
© 2003 Oxford University Press

Typical type 2 diabetes mellitus and HFE gene mutations: a population-based case – control study

David J. Halsall1,*, Ian McFarlane1, Jian'an Luan2, Timothy M. Cox3 and Nicholas J. Wareham2

1Department of Clinical Biochemistry, Addenbrooke's NHS Trust, Cambridge CB2 2QR, UK, 2Department of Public Health and Primary Care, Institute of Public Health, Cambridge University, Cambridge, UK and 3Department of Medicine, Addenbrooke's NHS Trust, Hills Road, Cambridge CB2 2QR, UK

Received March 12, 2003; Accepted April 3, 2003

Diabetes mellitus is a recognized consequence of hereditary haemochromatosis. Whether the common HFE mutations, that associate with this condition and pre-dispose to increases in serum iron indices, are over-represented in diabetic populations remains controversial. We present data from the largest case–control study of the C282Y and H63D HFE allele frequencies in typical type 2 diabetes mellitus, as defined by an age of onset greater than 30 years and no requirement for insulin in the first year post-diagnosis. We also present a meta-analysis of all similar studies to date. We see no evidence for over-representation of iron loading HFE alleles in type 2 diabetes mellitus, suggesting that screening for HFE mutations in this population is of no value.

* To whom correspondence should be addressed. Tel: +44 1223217156; Fax: +44 1223216862; Email: djh44{at}hermes.cam.ac.uk


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