Skip Navigation


Human Molecular Genetics Advance Access originally published online on September 9, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
12/21/2733    most recent
ddg314v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (14)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Morabia, A.
Right arrow Articles by Gilliam, T. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morabia, A.
Right arrow Articles by Gilliam, T. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Molecular Genetics, 2003, Vol. 12, No. 21 2733-2743
DOI: 10.1093/hmg/ddg314
© 2003 Oxford University Press

Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors

Alfredo Morabia1,*, Eftihia Cayanis2, Michael C. Costanza1, Barbara M. Ross2, Maria Sol Flaherty2, Gabriela B. Alvin2, Kamna Das2 and T. Conrad Gilliam2

1Division of Clinical Epidemiology, Geneva University Hospitals, 25 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland and 2Columbia Genome Center, and Departments of Genetics and Development, and Psychiatry, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA

Received April 30, 2003; Revised August 12, 2003; Accepted September 3, 2003

This study explored the genetic basis of the combination of extreme blood levels of HDL-C and LDL-C, a well-studied endophenotype for CVD, which has several attractive features as a target for genetic analysis: (1) the trait is moderately heritable; (2) non-genetic risk factors account for a significant but still limited portion of the phenotypic variance; (3) it is known to be moderated by a number of gene products. We exhaustively surveyed 11 candidate genes for allelic variation in a random population-based sample characterized for known CVD risk factors and blood lipid profiles. With the goal of generating specific etiological hypotheses, we compared two groups of subjects with extreme lipid phenotypes, from the same source population, using a case–control design. Cases (n=186) were subjects, within the total sample of 1708 people, who scored in the upper tertile of LDL-C and the lowest tertile of HDL-C, while controls (n=185) scored in the lowest tertile of LDL-C and the upper tertile of HDL-C. We used logistic regression and a four-tiered, systematic model building strategy with internal cross-validation and bootstrapping to investigate the relationships between the trait and 275 genetic variants in the presence of 10 non-genetic risk factors. Our results implicate a subset of nine genetic variants, spanning seven candidate genes, together with five environmental risk factors, in the etiology of extreme lipoprotein phenotypes. We propose a model involving these 14 genetic and non-genetic risk factors for evaluation in future independent studies.

* To whom correspondence should be addressed. Tel: +1 41223729552; Fax: +1 41223729565; Email: alfredo.morabia{at}hcuge.ch


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
T. Tanaka, J. Delgado-Lista, J. Lopez-Miranda, F. Perez-Jimenez, C. Marin, P. Perez-Martinez, P. Gomez, and J. M. Ordovas
Scavenger Receptor Class B Type I (SCARB1) c.1119C>T Polymorphism Affects Postprandial Triglyceride Metabolism in Men
J. Nutr., March 1, 2007; 137(3): 578 - 582.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
J. F. Thompson, L. S. Wood, E. H. Pickering, B. DeChairo, and C. L. Hyde
High-density genotyping and functional SNP localization in the CETP gene
J. Lipid Res., February 1, 2007; 48(2): 434 - 443.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
M. C. Costanza, E. Cayanis, B. M. Ross, M. S. Flaherty, G. B. Alvin, K. Das, and A. Morabia
Relative Contributions of Genes, Environment, and Interactions to Blood Lipid Concentrations in a General Adult Population
Am. J. Epidemiol., April 15, 2005; 161(8): 714 - 724.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. B. Lloyd, M. E. Lira, L. S. Wood, L. K. Durham, T. B. Freeman, G. M. Preston, X. Qiu, E. Sugarman, P. Bonnette, A. Lanzetti, et al.
Cholesteryl Ester Transfer Protein Variants Have Differential Stability but Uniform Inhibition by Torcetrapib
J. Biol. Chem., April 15, 2005; 280(15): 14918 - 14922.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
D. S. Hasin and B. F. Grant
The Co-occurrence of DSM-IV Alcohol Abuse in DSM-IV Alcohol Dependence: Results of the National Epidemiologic Survey on Alcohol and Related Conditions on Heterogeneity That Differ by Population Subgroup
Arch Gen Psychiatry, September 1, 2004; 61(9): 891 - 896.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
H. Knoblauch, A. Bauerfeind, M. R. Toliat, C. Becker, T. Luganskaja, U. P. Gunther, K. Rohde, H. Schuster, C. Junghans, F. C. Luft, et al.
Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol
Hum. Mol. Genet., May 15, 2004; 13(10): 993 - 1004.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.