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Human Molecular Genetics, 2003, Vol. 12, No. 6 595-600
© 2003 Oxford University Press

cDNA microarray analysis of individual Duchenne muscular dystrophy patients

Satoru Noguchi1,2, Toshifumi Tsukahara1,*, Masako Fujita1,2, Rumi Kurokawa1,2, Masaji Tachikawa2,3, Tatsushi Toda2,3, Atsumi Tsujimoto2,4, Kiichi Arahata1,2,{dagger} and Ichizo Nishino1,2

1Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan, 2Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation, Kawaguchi, Saitama 332-0012, Japan, 3Division of Functional Genomics, Department of Post-Genomics and Diseases, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan and 4DNA Chip Research Inc, Yokohama, Kanagawa 230-0045, Japan

Received October 1, 2002; Accepted January 17, 2003

We have developed a novel cDNA microarray encompassing 3500 genes expressed in skeletal muscle. With this system, we have performed the first study of gene expression in samples from individual patients. We analyzed muscle specimen from individuals with Duchenne muscular dystrophy to identify differences among patients. Among the variably expressed genes, we focused on the expression of the genes encoding HLA-related proteins, myosin light chains and troponin Ts as markers of muscle necrosis and regeneration. The expression patterns of these genes correlated with the severity of dystrophic changes on histological examination. Our cDNA microarray provides a new tool to investigate molecular muscle pathology.

* To whom correspondence should be addressed. Tel: +81 423412712; Fax: +81 423461742; Email: tukahara{at}ncnp.go.jp

{dagger} Deceased.


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