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Human Molecular Genetics, 2003, Vol. 12, Review Issue 1 R69-R73
DOI: 10.1093/hmg/ddg085
© 2003 Oxford University Press

Normal and abnormal dental development

Isabelle Miletich and Paul T. Sharpe*

Department of Craniofacial Development, GKT Dental Institute, King's College London, Guy's Hospital, London Bridge, London SE1 9RT, UK

Received January 8, 2003; Accepted February 5, 2003

Teeth are vertebrate organs that arise from complex and progressive interactions between an ectoderm, the oral epithelium and an underlying mesenchyme. During their early development, tooth germs exhibit many morphological and molecular similarities with other developing epithelial appendages, such as hair follicles, mammary and salivary glands, lungs, kidneys, etc. The developing mouse tooth germ, which is an experimentally accessible model for organogenesis, provides a powerful tool for elucidating the molecular mechanisms that control the development of these organs. Dentition patterning also provides a unique model for understanding how different shapes of teeth arise in different regions of the jaws. We review here the main signalling networks mediating the epithelial–mesenchymal interactions involved in tooth morphogenesis and patterning.

* To whom correspondence should be addressed. Email: paul.sharpe{at}kcl.ac.uk


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