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Human Molecular Genetics Advance Access originally published online on August 12, 2003
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Human Molecular Genetics, 2003, Vol. 12, Review Issue 2 R187-R193
DOI: 10.1093/hmg/ddg271
© 2003 Oxford University Press

Fly models of Huntington's disease

J. Lawrence Marsh1,*,{dagger}, Judit Pallos1 and Leslie M. Thompson2,{dagger}

1Department of Developmental and Cell Biology, University of California, Irvine, CA, USA and 2Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA

Received July 28, 2003; Accepted August 4, 2003

Can Drosophila models be engineered that accurately reflect Huntington's disease (HD) and other neurological diseases and can they contribute to the search for treatments and cures? A number of publications seem to provide a resounding yes to that question. Here we seek to review some of the salient features of these models.

* To whom correspondence should be addressed at: Department of Developmental and Cell Biology, 4244 McGaugh Hall, University of California, Irvine, CA 92697-2300, USA. Tel: +1 9498246677; Email: jlmarsh{at}uci.edu

{dagger} These authors contributed equally to this work.


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