Human Molecular Genetics Advance Access originally published online on April 28, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human Molecular Genetics, 2004, Vol. 13, No. 12 1205-1212
DOI: 10.1093/hmg/ddh137
Human Molecular Genetics, Vol. 13, No. 12 © Oxford University Press 2004; all rights reserved
Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations
1Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain, 2Department of Psychiatry, Hospital Principes d'España, L'Hospitalet de Llobregat, Barcelona, Spain, 3Department of Neuropsychiatric Sciences (DSNP), Fondazione Centro S. Raffaele del Monte Tabor, Milan, Italy, 4INSERM U 288, Neuropsychopharmacologie, CHU Pitié-Salpêtrière, Paris, France, 5University Psychiatric Hospital Ljubljana, Slovenia, 6University of Florence, Department of Neurology and Psychiatric Sciences, Viale Morgagni 85, 50134 Florence, Italy, 7CMME, Centre Hospitalier Sainte-Anne, 100 rue de la Santé, Paris, France, 8Medical Centre for Molecular Biology (MCMB), Faculty of Medicine, University of Ljubljana, Slovenia, 9Hôpital Louis Mourier (AP-HP), Service de Psychiatrie, 178 rue des Renouillers, Colombes, France, 10Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University Marburg, Germany, 11Eating Disorders Unit and SGDP Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK, 12University Clinic of Neuropsychiatry of Childhood and Adolescence, Waehringer Guertel 18–20, Vienna A-1090, Austria, 13CNRS UMR 7593-Paris VII, Personnalité et Conduites Adaptatives, CHU Pitié-Salpêtrière, Paris, France and 14Experimental and Health Sciences Department, Pompeu Fabra University, Barcelona Biomedical Research Park, Barcelona, Spain
Received March 3, 2004; Accepted April 7, 2004
Several genes with an essential role in the regulation of eating behavior and body weight are considered candidates involved in the etiology of eating disorders (ED), but no relevant susceptibility genes with a major effect on anorexia nervosa (AN) or bulimia nervosa (BN) have been identified. Brain-derived neurotrophic factor (BDNF) has been implicated in the regulation of food intake and body weight in rodents. We previously reported a strong association of the Met66 allele of the Val66Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients. Another single nucleotide polymorphism located in the promoter region of the BDNF gene (–270C>T) showed lack of association with any ED phenotype. In order to replicate these findings in a larger sample, we performed a case–control study in 1142 Caucasian patients with ED consecutively recruited in six different centers from five European countries (France, Germany, Italy, Spain and UK) participating in the ‘Factors in Healthy Eating’ project. We have found that the Met66 variant is strongly associated to all ED subtypes (AN, ANR, binge-eating/purging AN and BN), and that the –270C BDNF variant has an effect on BN and late age at onset of weight loss. These are the first two variants associated with the pathophysiology of ED in different populations and support a role for BDNF in the susceptibility to aberrant eating behaviors.
* To whom correspondence should be addressed at: Genes and Disease Program, Center for Genomic Regulation (CRG), Passeig Maritim, 37–49, 08003 Barcelona, Catalonia, Spain. Tel: +34 932240959; Fax: +34 932240899; Email: xavier.estivill{at}crg.es
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Licinio, C. Dong, and M.-L. Wong Novel Sequence Variations in the Brain-Derived Neurotrophic Factor Gene and Association With Major Depression and Antidepressant Treatment Response Arch Gen Psychiatry, May 1, 2009; 66(5): 488 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Byerly, J. Simon, E. Lebihan-Duval, M. J. Duclos, L. A. Cogburn, and T. E. Porter Effects of BDNF, T3, and corticosterone on expression of the hypothalamic obesity gene network in vivo and in vitro Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1180 - R1189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Foltynie, B Cheeran, C H Williams-Gray, M J Edwards, S A Schneider, D Weinberger, J C Rothwell, R A Barker, and K P Bhatia BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, February 1, 2009; 80(2): 141 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Mercader, E. Saus, Z. Aguera, M. Bayes, C. Boni, A. Carreras, E. Cellini, R. de Cid, M. Dierssen, G. Escaramis, et al. Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders Hum. Mol. Genet., May 1, 2008; 17(9): 1234 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Capellari, P. Parchi, P. Cortelli, P. Avoni, G. P. Casadei, C. Bini, A. Baruzzi, E. Lugaresi, M. Pocchiari, P. Gambetti, et al. SPORADIC FATAL INSOMNIA IN A FATAL FAMILIAL INSOMNIA PEDIGREE Neurology, March 11, 2008; 70(11): 884 - 885. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bullo, M. R Peeraully, P. Trayhurn, J Folch, and J. Salas-Salvado Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women Eur. J. Endocrinol., September 1, 2007; 157(3): 303 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. del Toro, J. M. Canals, S. Gines, M. Kojima, G. Egea, and J. Alberch Mutant huntingtin Impairs the Post-Golgi Trafficking of Brain-Derived Neurotrophic Factor But Not Its Val66Met Polymorphism J. Neurosci., December 6, 2006; 26(49): 12748 - 12757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Olesen, M. G Baker, T. Freund, M. di Luca, J. Mendlewicz, I. Ragan, and M. Westphal Consensus document on European brain research J. Neurol. Neurosurg. Psychiatry, August 1, 2006; 77(suppl_1): i1 - i49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Collier and J. L. Treasure The aetiology of eating disorders The British Journal of Psychiatry, November 1, 2004; 185(5): 363 - 365. [Full Text] [PDF]
|
|