Human Molecular Genetics Advance Access originally published online on August 4, 2004
Human Molecular Genetics 2004 13(19):2325-2332; doi:10.1093/hmg/ddh237
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human Molecular Genetics, Vol. 13, No. 19 © Oxford University Press 2004; all rights reserved
Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3
1Department of Endocrinology, Malmö University Hospital, Lund University, SE 205 02 Malmö, Sweden, 2Guy's, King's and St Thomas' School of Medicine, King's College London, Division of Genetics and Development, London, UK, 3Biocomputing Platforms Ltd, Espoo, Finland, 4Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, Utah, USA, 5Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA, 6NHLBI's Framingham Heart Study, Framingham, Massachusetts, USA, 7Department of Molecular Medicine, KTL, MOLS, Helsinki, Finland, 8Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA, 9Division of Biostatistics and Department of Genetics, Department of Psychiatry, and Department of Mathematics, Washington University in St Louis, St Louis, Missouri, USA, 10Division of Biostatistics, Washington University School of Medicine, St Louis, Missousi, USA and 11Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
Received June 1, 2004; Revised July 1, 2004; Accepted July 23, 2004
Individual genome-wide scans of blood pressure (BP) and hypertension (HT) have shown inconsistent results. The aim of this study was to investigate whether there was any consistent evidence of linkage across multiple studies with similar ethnicity. We applied the genome-search meta-analysis method (GSMA) to nine published genome-wide scans of BP (n=5) and HT (n=4) from Caucasian populations. For each study, the genome was divided into 120 bins and ranked according to the maximum evidence of linkage within each bin. The ranks were summed and averaged across studies and significance levels were estimated, on the basis of a distribution function of summed ranks or permutation tests without (PU) or with (PW) a study sample size weighting factor. Chromosome 3p14.1–q12.3 showed consistent evidence of linkage to HT (PU=0.0001 and PW=0.0001), diastolic BP (DBP) (PU=0.007 and PW=0.02), HT and DBP pooled (PU=0.00002 and PW=0.0001) and HT and systolic BP (SBP) pooled (PU=0.0003 and PW=0.0005). Chromosome 2p12–q22.1 showed evidence of linkage to HT (PU=0.003 and PW=0.009), DBP (PU=0.05 and PW=NS), HT and DBP pooled (PU=0.001 and PW=0.004) and HT and SBP pooled (PU=0.001 and PW=0.005). The summed ranks of the HT analysis correlated significantly with those of the DBP (r=0.20, P=0.03) but not with those of the SBP. Both loci showed clustering of significant bins in the analysis of HT and DBP. We conclude that modest or non-significant linkage on chromosomes 3p14.1–q12.3 and 2p12–q22.1 in each individual study translates into genome-wide significant or highly suggestive linkages to HT and DBP in our GSMA analysis.
* To whom correspondence should be addressed. Tel: +46 40336023, Fax: +46 40337042, Email: olle.melander{at}endo.mas.lu.se
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Shi, C. C. Gu, A. T. Kraja, D. K. Arnett, R. H. Myers, J. S. Pankow, S. C. Hunt, and D. C. Rao Genetic Effect on Blood Pressure Is Modulated by Age: The Hypertension Genetic Epidemiology Network Study Hypertension, January 1, 2009; 53(1): 35 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Deng Genetic basis of polygenic hypertension Hum. Mol. Genet., October 15, 2007; 16(R2): R195 - R202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Arnett, A. E. Baird, R. A. Barkley, C. T. Basson, E. Boerwinkle, S. K. Ganesh, D. M. Herrington, Y. Hong, C. Jaquish, D. A. McDermott, et al. Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, June 5, 2007; 115(22): 2878 - 2901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Carter, A. Pluzhnikov, A. E. Timms, C. Miceli-Richard, C. Bourgain, B. P. Wordsworth, H. Jean-Pierre, N. J. Cox, L. J. Palmer, M. Breban, et al. Combined analysis of three whole genome linkage scans for Ankylosing Spondylitis Rheumatology, May 1, 2007; 46(5): 763 - 771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kalmyrzaev, A. Aldashev, M. Khalmatov, A. Polupanov, A. Jumagulova, L. Mamanova, M. R. Wilkins, and M. Town Genome-Wide Scan for Premature Hypertension Supports Linkage to Chromosome 2 in a Large Kyrgyz Family Hypertension, November 1, 2006; 48(5): 908 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Munroe, C. Wallace, M.-Z. Xue, A. C. B. Marcano, R. J. Dobson, A. K. Onipinla, B. Burke, J. Gungadoo, S. J. Newhouse, J. Pembroke, et al. Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study Hypertension, July 1, 2006; 48(1): 105 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Fisher, G. R. Abecasis, B. M. Yashar, S. Zareparsi, A. Swaroop, S. K. Iyengar, B. E.K. Klein, R. Klein, K. E. Lee, J. Majewski, et al. Meta-analysis of genome scans of age-related macular degeneration Hum. Mol. Genet., August 1, 2005; 14(15): 2257 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Dominiczak, D. Graham, M. W. McBride, N. J.R. Brain, W. K. Lee, F. J. Charchar, M. Tomaszewski, C. Delles, and C. A. Hamilton Cardiovascular Genomics and Oxidative Stress Hypertension, April 1, 2005; 45(4): 636 - 642. [Abstract] [Full Text] [PDF]
|
|