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Human Molecular Genetics Advance Access originally published online on December 8, 2003
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Human Molecular Genetics, 2004, Vol. 13, No. 3 295-302
DOI: 10.1093/hmg/ddh029

Expression of complement components in the peripheral nervous system

Rosalein R. de Jonge1, Ivo N. van Schaik2, Jeroen P. Vreijling1, Dirk Troost3 and Frank Baas1,2,*

1Neurogenetics Laboratory, 2Department of Neurology and 3Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands

Received August 28, 2003; Revised November 15, 2003; Accepted November 27, 2003

We have generated a SAGE (serial analysis of gene expression) library of normal sciatic nerve and found tags encoding for mRNAs of the complement system highly represented. RNA (RT–PCR and northern blot hybridization) and protein (western blot analysis and immunohistochemistry) studies confirmed these findings. High expression of classical pathway components, alternative pathway components and inhibitory components was observed in specific regions of the sciatic nerve. The first components of complement were found in axons, whereas the inhibitory components were detected in the perineurium, thereby protecting the nerve from a complement attack. Immunoreactivity towards activated complement factors was noted in post traumatic neuromas and after acute crush injury, which exemplify nerve regeneration and degeneration. We propose that local production of complement in the peripheral nervous system participates in the protection of healthy nerve and is needed for efficient clearance of myelin after injury: a prerequisite for normal regeneration and remyelination of the peripheral nerve.

* To whom correspondence should be addressed at: Neurogenetics Laboratory, Academic Medical Center, K2-213, PO Box 22660, 1100 AD Amsterdam, The Netherlands. Tel: +31 205665998; Fax: +31 205669312; Email: f.baas{at}amc.uva.nl


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