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Human Molecular Genetics 2004 13(Review Issue 2):R267-R273; doi:10.1093/hmg/ddh248
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Human Molecular Genetics, Vol. 13, Review Issue 2 © Oxford University Press 2004; all rights reserved

‘Am not I a fly like thee?’ From genes in fruit flies to behavior in humans

Ralph J. Greenspan* and Herman A. Dierick

The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92118, USA

Received June 14, 2004; Accepted July 26, 2004

The fruit fly Drosophila melanogaster has provided insight into the role of genes in behavior, some of which have relevant implications for humans. Mutants induced or engineered in the laboratory have contributed to our understanding of biological rhythms, learning, memory, neurodegenerative disease and drug response. Studies of naturally occurring genetic variation in behavior have advanced our understanding of what kinds of variants arise spontaneously and contribute to behavior.

* To whom correspondence should be addressed. Tel: +1 8586262075; Fax: +1 8586262099; Email: greenspan{at}nsi.edu


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