Skip Navigation


Human Molecular Genetics Advance Access originally published online on August 22, 2005
Human Molecular Genetics 2005 14(19):2779-2786; doi:10.1093/hmg/ddi311
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
14/19/2779    most recent
ddi311v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Matsuda, A.
Right arrow Articles by Shirakawa, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Matsuda, A.
Right arrow Articles by Shirakawa, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma

Akira Matsuda1,*, Tomomitsu Hirota1, Mitsuteru Akahoshi1, Makiko Shimizu1, Mayumi Tamari1, Akihiko Miyatake3, Atsushi Takahashi2, Kazuko Nakashima1,4, Naomi Takahashi1, Kazuhiko Obara1, Noriko Yuyama5, Satoru Doi6, Yumiko Kamogawa7, Tadao Enomoto9, Koichi Ohshima10, Tatsuhiko Tsunoda2, Shoichiro Miyatake7, Kimie Fujita11, Moriaki Kusakabe12, Kenji Izuhara13, Yusuke Nakamura8, Julian Hopkin14 and Taro Shirakawa1,4

1Laboratory for Genetics of Allergic Diseases and 2Laboratory for Medical Informatics, SNP Research Center, RIKEN, Yokohama, Japan, 3Miyatake Asthma Clinic, Osaka, Japan, 4Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Public Health, Kyoto, Japan, 5Genox Research Inc., Kawasaki, Japan, 6Osaka Prefectural Habikino Hospital, Osaka, Japan, 7Department of Molecular and Developmental Biology and 8Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan, 9Department of Otolaryngology, Japanese Red Cross Society, Wakayama Medical Center, Wakayama, Japan, 10Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan, 11College of Nursing, University of Shiga, Shiga, Japan, 12Experimental Animal Research Center, Institute for Animal Reproduction, Ibaraki, Japan, 13Department of Biomolecular Sciences, Saga Medical School, Saga, Japan and 14Experimental Medicine Unit, University of Wales Swansea, Swansea, UK

* To whom correspondence should be addressed at: Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Suehiro 1-7-22, Tsurumi-KU, Yokohama 230-0045, Japan. Tel: +81 455039616; Fax: +81 455039615; Email: akimatsu{at}src.riken.go.jp

Received June 20, 2005; Accepted August 9, 2005

The extracellular matrix glycoprotein tenascin-C (TNC) has been accepted as a valuable histopathological subepithelial marker for evaluating the severity of asthmatic disease and the therapeutic response to drugs. We found an association between an adult asthma and an SNP encoding TNC fibronectin type III-D (Fn-III-D) domain in a case–control study between a Japanese population including 446 adult asthmatic patients and 658 normal healthy controls. The SNP (44513A/T in exon 17) strongly associates with adult bronchial asthma ({chi}2 test, P=0.00019, Odds ratio=1.76, 95% confidence interval=1.31–2.36). This coding SNP induces an amino acid substitution (Leu1677Ile) within the Fn-III-D domain of the alternative splicing region. Computer-assisted protein structure modeling suggests that the substituted amino acid locates at the outer edge of the beta-sheet in Fn-III-D domain and causes instability of this beta-sheet. As the TNC fibronectin-III domain has molecular elasticity, the structural change may affect the integrity and stiffness of asthmatic airways. In addition, TNC expression in lung fibroblasts increases with Th2 immune cytokine stimulation. Thus, Leu1677Ile may be valuable marker for evaluating the risk for developing asthma and plays a role in its pathogenesis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. C. Snyder, A. C. Zemke, and B. R. Stripp
Reparative Capacity of Airway Epithelium Impacts Deposition and Remodeling of Extracellular Matrix
Am. J. Respir. Cell Mol. Biol., June 1, 2009; 40(6): 633 - 642.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Orsmark-Pietras, E. Melen, J. Vendelin, S. Bruce, A. Laitinen, L. A. Laitinen, R. Lauener, J. Riedler, E. von Mutius, G. Doekes, et al.
Biological and genetic interaction between Tenascin C and Neuropeptide S receptor 1 in allergic diseases
Hum. Mol. Genet., June 1, 2008; 17(11): 1673 - 1682.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Harada, K. Nakashima, T. Hirota, M. Shimizu, S. Doi, K. Fujita, T. Shirakawa, T. Enomoto, M. Yoshikawa, H. Moriyama, et al.
Functional Polymorphism in the Suppressor of Cytokine Signaling 1 Gene Associated with Adult Asthma
Am. J. Respir. Cell Mol. Biol., April 1, 2007; 36(4): 491 - 496.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
A. V September, M. P Schwellnus, M. Collins, and W. Gibson
Tendon and ligament injuries: the genetic component * COMMENTARY
Br. J. Sports Med., April 1, 2007; 41(4): 241 - 246.
[Full Text] [PDF]

Home page
 IOVSHome page
K. E. Keller, M. J. Kelley, and T. S. Acott
Extracellular Matrix Gene Alternative Splicing by Trabecular Meshwork Cells in Response to Mechanical Stretching
Invest. Ophthalmol. Vis. Sci., March 1, 2007; 48(3): 1164 - 1172.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. Matsuda, N. Ebihara, N. Kumagai, K. Fukuda, K. Ebe, K. Hirano, C. Sotozono, M. Tei, K. Hasegawa, M. Shimizu, et al.
Genetic Polymorphisms in the Promoter of the Interferon Gamma Receptor 1 Gene Are Associated with Atopic Cataracts
Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 583 - 589.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. Vendelin, S. Bruce, P. Holopainen, V. Pulkkinen, P. Rytila, A. Pirskanen, M. Rehn, T. Laitinen, L. A. Laitinen, T. Haahtela, et al.
Downstream target genes of the neuropeptide S-NPSR1 pathway
Hum. Mol. Genet., October 1, 2006; 15(19): 2923 - 2935.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.