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Human Molecular Genetics Advance Access originally published online on October 12, 2005
Human Molecular Genetics 2005 14(22):3499-3506; doi:10.1093/hmg/ddi379
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© The Author 2005. Published by Oxford University Press. All rights reserved.
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Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease

Keiko Yamazaki1, Dermot McGovern2,3, Jiannis Ragoussis2, Marta Paolucci2, Helen Butler2, Derek Jewell2,3, Lon Cardon2, Masakazu Takazoe4, Torao Tanaka4, Toshiki Ichimori5, Susumu Saito6, Akihiro Sekine6, Aritoshi Iida6, Atsushi Takahashi7, Tatsuhiko Tsunoda7, Mark Lathrop8 and Yusuke Nakamura1,6,*

1Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 2The Wellcome Trust Centre for Human Genetics, 3Gastroenterology Unit, University of Oxford, Oxford, UK, 4Division of Gastroenterology, Department of Medicine, Social Insurance Chuo General Hospital, Tokyo, Japan, 5Division of Gastroenterology, Department of Medicine, Suzaki Kuroshio Hospital, Kouchi, Japan, 6Laboratory for Genotyping and 7Laboratory for Medical Informatics, SNP Research Center, RIKEN, Yokohama, Japan and 8Centre National de Genotypage, Evry Cedex, France

* To whom correspondence should be addressed at: Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 354495372; Fax: +81 354495433; Email: yusuke{at}ims.u-tokyo.ac.jp

Received March 25, 2005; Revised July 17, 2005; Accepted September 23, 2005

The inflammatory bowel diseases (IBDs), Crohn's disease (CD) and ulcerative colitis, are chronic inflammatory disorders of the digestive tract. The pathogenesis of IBD is complicated, and it is widely accepted that immunologic, environmental and genetic components contribute to its etiology. To identify genetic susceptibility factors in CD, we performed a genome-wide association study in Japanese patients and controls using nearly 80 000 gene-based single nucleotide polymorphism (SNP) markers and investigated the haplotype structure of the candidate locus in Japanese and European patients. We identified highly significant associations (P=1.71x10–14 with odds ratio of 2.17) of SNPs and haplotypes within the TNFSF15 (the gene encoding tumor necrosis factor superfamily, member 15) genes in Japanese CD patients. The association was confirmed in the study of two European IBD cohorts. Interestingly, a core TNFSF15 haplotype showing association with increased risk to the disease was common in the two ethnic groups. Our results suggest that the genetic variations in the TNFSF15 gene contribute to the susceptibility to IBD in the Japanese and European populations.


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