Skip Navigation

Human Molecular Genetics 2005 14(Review Issue 2):R197-R205; doi:10.1093/hmg/ddi265
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Glover, T. W.
Right arrow Articles by Durkin, S. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Glover, T. W.
Right arrow Articles by Durkin, S. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Mechanisms of common fragile site instability

Thomas W. Glover*, Martin F. Arlt, Anne M. Casper and Sandra G. Durkin

Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA

* To whom correspondence should be addressed at: Department of Human Genetics, University of Michigan, 4909 Buhl, PO Box 0618, 1241 E. Catherine Street, Ann Arbor, MI 48109-0618, USA. Tel: +1 7347635222; Fax: +1 7347633784; Email: glover{at}umich.edu

Received July 6, 2005; Accepted July 14, 2005

The study of common fragile sites has its roots in the early cytogenetic investigations of the fragile X syndrome. Long considered an interesting component of chromosome structure, common fragile sites have taken on novel significance as regions of the genome that are particularly sensitive to certain forms of replication stress, which are frequently rearranged in cancer cells. In recent years, much has been learned about the genomic structure at fragile sites and the cellular checkpoint functions that monitor their stability. Recent findings suggest that common fragile sites may serve as markers of chromosome damage caused by replication stress during early stages of tumorigenesis. Thus, the study of common fragile sites can provide insight not only into the nature of fragile sites, but also into the broader consequences of replication stress on DNA damage and cancer. However, despite recent advances, many questions remain regarding the normal functional significance of these conserved regions and the basis of their fragility.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Genes Dev.Home page
J. T. Huse, C. Brennan, D. Hambardzumyan, B. Wee, J. Pena, S. H. Rouhanifard, C. Sohn-Lee, C. le Sage, R. Agami, T. Tuschl, et al.
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
Genes & Dev., June 1, 2009; 23(11): 1327 - 1337.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
H. Inagaki, T. Ohye, H. Kogo, T. Kato, H. Bolor, M. Taniguchi, T. H. Shaikh, B. S. Emanuel, and H. Kurahashi
Chromosomal instability mediated by non-B DNA: Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans
Genome Res., February 1, 2009; 19(2): 191 - 198.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
L. M. Pirzio, P. Pichierri, M. Bignami, and A. Franchitto
Werner syndrome helicase activity is essential in maintaining fragile site stability
J. Cell Biol., January 28, 2008; 180(2): 305 - 314.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
K. Debacker and R.F. Kooy
Fragile sites and human disease
Hum. Mol. Genet., October 15, 2007; 16(R2): R150 - R158.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. Zhu and R. S. Weiss
Increased Common Fragile Site Expression, Cell Proliferation Defects, and Apoptosis following Conditional Inactivation of Mouse Hus1 in Primary Cultured Cells
Mol. Biol. Cell, March 1, 2007; 18(3): 1044 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. A. Lovejoy, K. Lock, A. Yenamandra, and D. Cortez
DDB1 Maintains Genome Integrity through Regulation of Cdt1
Mol. Cell. Biol., November 1, 2006; 26(21): 7977 - 7990.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.