Skip Navigation

Human Molecular Genetics 2005 14(Review Issue 2):R275-R282; doi:10.1093/hmg/ddi263
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Thapar, A.
Right arrow Articles by Owen, M. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thapar, A.
Right arrow Articles by Owen, M. J
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The genetics of attention deficit hyperactivity disorder

Anita Thapar*, Michael O'Donovan and Michael J Owen

Department of Psychological Medicine, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK

* To whom correspondence should be addressed. Email: thapar{at}cardiff.ac.uk

Received June 22, 2005; Accepted July 6, 2005

Attention deficit hyperactivity disorder (ADHD) is a highly heritable, disruptive, childhood-onset condition, the aetiology and pathogenesis of which is poorly understood. There have been relatively few genome-wide linkage studies, and no chromosomal region has yet been unequivocally implicated. In contrast, evidence from pharmacological, neuroimaging and animal studies has suggested the involvement of specific neurotransmitter systems, notably dopaminergic pathways, in ADHD and these aetiological clues have inspired a fruitful application of the candidate gene association approach. Meta-analyses or pooled data analyses have supported association between ADHD and polymorphisms in DRD4, DRD5 and SLC6A3 which encode dopamine D4 and D5 receptors and the dopamine transporter, respectively. A weaker, but nevertheless replicated, body of evidence also supports associations with SNAP-25 (synaptosomal-associated protein, 25 kDa) and SLC6A4 (serotonin transporter). There is increasing research interest in gene-phenotype links, clinical phenotypic markers of heterogeneity and gene–environment interaction, which are likely to be important in the next generation of genetic studies.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JNMHome page
E. M. van de Giessen, M. M.L. de Win, M. W.T. Tanck, W. van den Brink, F. Baas, and J. Booij
Striatal Dopamine Transporter Availability Associated with Polymorphisms in the Dopamine Transporter Gene SLC6A3
J. Nucl. Med., January 1, 2009; 50(1): 45 - 52.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
A. Caspi, K. Langley, B. Milne, T. E. Moffitt, M. O'Donovan, M. J. Owen, M. Polo Tomas, R. Poulton, M. Rutter, A. Taylor, et al.
A Replicated Molecular Genetic Basis for Subtyping Antisocial Behavior in Children With Attention-Deficit/Hyperactivity Disorder
Arch Gen Psychiatry, February 1, 2008; 65(2): 203 - 210.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
M. M. Segal, G. F. Rogers, H. L. Needleman, and C. A. Chapman
Hypokalemic Sensory Overstimulation
J Child Neurol, December 1, 2007; 22(12): 1408 - 1410.
[Abstract] [PDF]

Home page
 J PsychopharmacolHome page
D. J. Nutt, K. Fone, P. Asherson, D. Bramble, P. Hill, K. Matthews, K. A. Morris, P. Santosh, E. Sonuga-Barke, E. Taylor, et al.
Evidence-based guidelines for management of attention-deficit/hyperactivity disorder in adolescents in transition to adult services and in adults: recommendations from the British Association for Psychopharmacology
J Psychopharmacol, January 1, 2007; 21(1): 10 - 41.
[Abstract] [PDF]

Home page
 Br. J. PsychiatryHome page
A. THAPAR, K. LANGLEY, P. ASHERSON, and M. GILL
Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective
The British Journal of Psychiatry, January 1, 2007; 190(1): 1 - 3.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.