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Human Molecular Genetics Advance Access originally published online on June 29, 2006
Human Molecular Genetics 2006 15(15):2392-2399; doi:10.1093/hmg/ddl163
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The human X chromosome is enriched for germline genes expressed in premeiotic germ cells of both sexes

Michael Koslowski, Ugur Sahin{dagger}, Christoph Huber and Özlem Türeci*,{dagger}

Department of Internal Medicine III, Johannes Gutenberg-University, Obere Zahlbacher Street 63, 55131 Mainz, Germany

* To whom correspondence should be addressed. Tel: +49 61313933396; Fax: +49 61313933343; Email: tureci{at}uni-mainz.de

Received May 28, 2006; Accepted June 22, 2006

The role of X-chromosomal genes in spermatogenesis has been subject to a number of studies in different organisms. Recently, it was proposed that the X chromosome has a predominant role in premeiotic stages of mammalian spermatogenesis. We analyzed the expression of a representative set of 17 X-linked and 48 autosomal germline-restricted genes in different stages of human germ cell development. In accordance with data from other species, we show that the human X chromosome is indeed significantly enriched for genes activated in premeiotic stages of spermatogenesis. In contrast to recent studies, however, we found that expression of these genes is not restricted to spermatogenesis, but is activated in oogenesis as well. Furthermore, we show that activation of this subset of genes merely depends on demethylation of their promoter regions. Moreover, our data suggest that genes activated in premeiotic stages of gametogenesis are sex-indifferent and are regulated by DNA methylation. Gene activation patterns involved in spermatocyte-specific differentiation, in contrast, appear to be initiated not before entry into meiosis and underlie a more complex regulation, presumably involving specific transcription factors and/or chromatin remodeling mechanisms.

{dagger} Both the authors contributed equally.


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