Human Molecular Genetics Advance Access originally published online on August 7, 2006
Human Molecular Genetics 2006 15(18):2721-2731; doi:10.1093/hmg/ddl206
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Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli
1 Laboratory of Molecular Psychobiology, Department of Psychiatry and Behavioral Sciences and 2 Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA, 3 Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Zonal Avenue, Los Angeles, CA 90089-9121, USA and 4 Faculty of Pharmacy, University of Paris-Sud, 92296 Chatenay-Malabry, France
* To whom correspondence should be addressed. Tel: +1 7184303124; Fax: +1 7184303125; Email: hiroi{at}aecom.yu.edu
Received June 15, 2006; Accepted July 28, 2006
Nicotine is thought to act on brain monoamine systems that normally mediate diverse motivational behaviors. How monoamine-related genes contribute to behavioral traits (e.g. responses to novel stimuli) comorbid with the susceptibility to nicotine addiction is still poorly understood. We examined the impact of constitutive monoamine oxidase A (MAOA) deficiency in mice on nicotine reward and responses to novel stimuli. Age-matched, male Maoa-knockout (KO) mice and wild-type (WT) littermates were tested for nicotine-induced conditioned place preference (CPP); voluntary oral nicotine preference/intake; spontaneous locomotor activity in a novel, inescapable open field; and novelty place preference. Nicotine preference in WT mice was reduced in Maoa-KO mice in the CPP and oral preference/intake tests. Control experiments showed that these phenotypes were not due to abnormalities in nicotine metabolism, fluid intake or response to taste. In contrast, Maoa-KO mice were normal in their behavioral response to a novel, inescapable open field and in their preference for a novel place. The observed phenotypes suggest that a constitutive deficiency of MAOA reduces the rewarding effects of nicotine without altering behavioral responses to novel stimuli in mice. Constitutive MAOA activity levels are likely to contribute to the vulnerability or resiliency to nicotine addiction by altering the rewarding effects of nicotine.
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