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Human Molecular Genetics Advance Access originally published online on September 28, 2006
Human Molecular Genetics 2006 15(21):3241-3250; doi:10.1093/hmg/ddl402
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior

Ichiko Nishijima1,2,*, Takanori Yamagata2,5, Corinne M. Spencer2, Edwin J. Weeber3,6, Olga Alekseyenko2, J. David Sweatt3, Mariko Y. Momoi5, Masayuki Ito7, Dawna L. Armstrong4, David L. Nelson2, Richard Paylor2,3 and Allan Bradley2,8

1 Center for Molecular and Human Genetics, Columbus Children's Research Institute, The Ohio State University, Columbus, OH 43205, USA, 2 Department of Molecular and Human Genetics, 3 Division of Neuroscience and 4 Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA, 5 Department of Pediatrics, Jichi Medical School, Tochigi 329-0498, Japan, 6 Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA, 7 National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan and 8 The Wellcome Trust Sanger Institute, Cambridge, UK

* To whom correspondence should be addressed. Tel: +1 6143553508; Fax: +1 6147222817; Email: nishijii{at}pediatrics.ohio-state.edu

Received July 6, 2006; Accepted September 18, 2006

Secretin is a peptide hormone released from the duodenum to stimulate the secretion of digestive juice by the pancreas. Secretin also functions as a neuropeptide hormone in the brain, and exogenous administration has been reported to alleviate symptoms in some patients with autism. We have generated secretin receptor-deficient mice to explore the relationship between secretin signaling in the brain and behavioral phenotypes. Secretin receptor-deficient mice are overtly normal and fertile; however, synaptic plasticity in the hippocampus is impaired and there are slightly fewer dendritic spines in the CA1 hippocampal pyramidal cells. Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior.


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