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Human Molecular Genetics Advance Access originally published online on January 18, 2006
Human Molecular Genetics 2006 15(5):717-724; doi:10.1093/hmg/ddi485
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Allele-specific deposition of macroH2A1 in imprinting control regions

Jung Ha Choo1,2, Jeong Do Kim1, Jae Hoon Chung2, Lisa Stubbs3 and Joomyeong Kim1,*

1Department of Biological Sciences, Center for BioModular Multi-scale Systems, Louisiana State University, Baton Rouge, LA 70803, USA, 2Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea and 3Genome Biology Division, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA

* To whom correspondence should be addressed. Tel: +1 2255787692; Fax: +1 2255782597; Email: jkim{at}lsu.edu

Received November 22, 2005; Accepted January 12, 2006

In the current study, we analyzed the deposition patterns of macroH2A1 at a number of different genomic loci located in X chromosome and autosomes. MacroH2A1 is preferentially deposited at methylated CpG-rich regions located close to promoters. The macroH2A1 deposition patterns at the methylated CpG islands of several imprinted domains, including the imprinting control regions (ICRs) of Xist, Peg3, H19/Igf2, Gtl2/Dlk1 and Gnas domains, show consistent allele-specificity towards inactive, methylated alleles. The macroH2A1 deposition levels at the ICRs and other differentially methylated regions of these domains are also either higher or comparable to those observed at the inactive X chromosome of female mammals. Overall, our results indicate that besides DNA methylation macroH2A1 is another epigenetic component in the chromatin of ICRs displaying differential association with two parental alleles.


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