Skip Navigation

Human Molecular Genetics 2007 16(R2):R203-R208; doi:10.1093/hmg/ddm243
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hassold, T.
Right arrow Articles by Hunt, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hassold, T.
Right arrow Articles by Hunt, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The origin of human aneuploidy: where we have been, where we are going

Terry Hassold*, Heather Hall and Patricia Hunt

School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA

* To whom correspondence should be addressed. Tel: +1 5093355537; Fax: +1 5093359688; Email: terryhassold{at}wsu.edu

Received August 16, 2007; Accepted August 22, 2007

Aneuploidy is the most common chromosome abnormality in humans, and is the leading genetic cause of miscarriage and congenital birth defects. Since the identification of the first human aneuploid conditions nearly a half-century ago, a great deal of information has accrued on its origin and etiology. We know that most aneuploidy derives from errors in maternal meiosis I, that maternal age is a risk factor for most, if not all, human trisomies, and that alterations in recombination are an important contributor to meiotic non-disjunction. In this review, we summarize some of the data that have led to these conclusions, and discuss some of the approaches now being used to address the underlying causes of meiotic non-disjunction in humans.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
X. Huang, C. V. Andreu-Vieyra, M. Wang, A. J. Cooney, M. M. Matzuk, and P. Zhang
Preimplantation Mouse Embryos Depend on Inhibitory Phosphorylation of Separase To Prevent Chromosome Missegregation
Mol. Cell. Biol., March 15, 2009; 29(6): 1498 - 1505.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
J. E. Holt and K. T. Jones
Control of homologous chromosome division in the mammalian oocyte
Mol. Hum. Reprod., March 1, 2009; 15(3): 139 - 147.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
D. Wells, S. Alfarawati, and E. Fragouli
Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH
Mol. Hum. Reprod., December 1, 2008; 14(12): 703 - 710.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Fragouli, M. Lenzi, R. Ross, M. Katz-Jaffe, W.B. Schoolcraft, and D. Wells
Comprehensive molecular cytogenetic analysis of the human blastocyst stage
Hum. Reprod., November 1, 2008; 23(11): 2596 - 2608.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Duchon, V. Besson, P. L. Pereira, L. Magnol, and Y. Herault
Inducing Segmental Aneuploid Mosaicism in the Mouse Through Targeted Asymmetric Sister Chromatid Event of Recombination
Genetics, September 1, 2008; 180(1): 51 - 59.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L. Uroz, O. Rajmil, and C. Templado
Premature separation of sister chromatids in human male meiosis
Hum. Reprod., April 1, 2008; 23(4): 982 - 987.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.