Skip Navigation

Human Molecular Genetics 2008 17(R1):R23-R27; doi:10.1093/hmg/ddn050
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Chen, L.
Right arrow Articles by Daley, G. Q.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, L.
Right arrow Articles by Daley, G. Q.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Human Molecular Genetics issue: Stem Cells and Regeneration [View the issue table of contents]

Molecular basis of pluripotency

Lingyi Chen1 and George Q. Daley1,2,3,4,5,*

1 Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA 2 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA 3 Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA, 4 Harvard Stem Cell Institute, Boston, MA 02115, USA 5 Howard Hughes Medical Institute, MD, USA

* To whom correspondence should be addressed. Email: george.daley{at}childrens.harvard.edu

Received December 31, 2007; Accepted February 13, 2008

Embryonic stem (ES) cells are pluripotent and capable of self-renewal, thus holding promise for regenerative medicine. Recent studies have begun to provide insights into the molecular mechanisms underlying pluripotency and self-renewal. In this article, we discuss the roles of transcriptional regulation, epigenetic regulation and miRNAs in the maintenance of pluripotency and the differentiation of ES cells.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
J. Butcher, H. Abdou, K. Morin, and Y. Liu
Micromanaging Oligodendrocyte Differentiation by Noncoding RNA: Toward a Better Understanding of the Lineage Commitment Process
J. Neurosci., April 29, 2009; 29(17): 5365 - 5366.
[Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
P. Rangan, M. DeGennaro, and R. Lehmann
Regulating Gene Expression in the Drosophila Germ Line
Cold Spring Harb Symp Quant Biol, March 6, 2009; (2009) sqb.2008.73.057v1.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.