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Human Molecular Genetics 2009 18(R2):R163-R168; doi:10.1093/hmg/ddp396
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Cancer genome sequencing: a review

Elaine R. Mardis* and Richard K. Wilson

The Genome Center, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA

* To whom correspondence should be addressed at: Department of Genetics, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, MO 63108, USA. Tel: +1 3142861805; Fax: +1 3142861810; Email: emardis{at}wustl.edu

Received July 5, 2009; Accepted August 17, 2009

A genomic era of cancer studies is developing rapidly, fueled by the emergence of next-generation sequencing technologies that provide exquisite sensitivity and resolution. This article discusses several areas within cancer genomics that are being transformed by the application of new technology, and in the process are dramatically expanding our understanding of this disease. Although, we anticipate that there will be many exciting discoveries in the near future, the ultimate success of these endeavors rests on our ability to translate what is learned into better diagnosis, treatment and prevention of cancer.


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