Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Islam, S. D.
Right arrow Articles by M.Silver, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Islam, S. D.
Right arrow Articles by M.Silver, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 Oxford University Press

RESEARCH-ARTICLE

The human homolog of a candidate mouse t complex responder gene: conserved motifs and evolution with punctuated equilibria

Salim D. Islam, Stephen H. Pllder+, Cindy L. Decker, Judith A. Cebra-Thomas and Lee M.Silver*

Department of Molecular Biology, Princeton University Princeton, NJ 08544–1014, USA

*To whom correspondence should be addressed

Received August 17, 1993; Revised October 22, 1993; Accepted October 22, 1993

The mouse Tcp-10 gene has been established as a molecular candidate for the t complex responder locus which plays a central role in the transmission ratio distortion phenotype expressed by males heterozygous for a t haplotype. Here we describe a comparison of the mouse and human TCP10 coding sequences. The results show that whole exons have been added or eliminated from the transcripts expressed in each species, suggesting an evolutionary process of punctuated equilibria for this gene. Two of the polypeptide regions that are most conserved between the two species contain specific peptide motifs. The conserved C-terminal region contains a unique nonapeptide repeat of unknown function and the conserved N-terminal region contains a pair of leucine zippers within a region that shows additional similarity to the coiled-coil regions of various cytosolic polypeptides. These results are discussed in terms of the possible function of the TCP10 protein.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
M. G. Tibiletti, B. Bernasconi, D. Furlan, P. Bressan, R. Cerutti, C. Facco, M. Franchi, C. Riva, R. Cinquetti, C. Capella, et al.
Chromosome 6 Abnormalities in Ovarian Surface Epithelial Tumors of Borderline Malignancy Suggest a Genetic Continuum in the Progression Model of Ovarian Neoplasms
Clin. Cancer Res., November 1, 2001; 7(11): 3404 - 3409.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L.-Y. Hung, C.-J. C. Tang, and T. K. Tang
Protein 4.1 R-135 Interacts with a Novel Centrosomal Protein (CPAP) Which Is Associated with the gamma -Tubulin Complex
Mol. Cell. Biol., October 15, 2000; 20(20): 7813 - 7825.
[Abstract] [Full Text]

Home page
 Genome ResHome page
W Makalowski, J Zhang, and M S Boguski
Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.
Genome Res., September 1, 1996; 6(9): 846 - 857.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.