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© 1993 Oxford University Press

RESEARCH-ARTICLE

The insulin-like growth factor 1 receptor gene is normally biallelically expressed in human juvenile tissue and tumours

Tammy K. Howard, Elizabeth M. Algar, Jane A. Glatz, Anthony E. Reeve1 and Peter J. Smith*

Queensland Cancer Fund Research Unit, Department of Pathology, University of Queensland Medical School Herston 4006, Queensland, Australia 1Cancer Genetics Laboratory, Department of Biochemistry, University of Otago Dunedin, New Zealand

*To whom correspondence should be addressed

Received August 25, 1993; Revised October 21, 1993; Accepted October 21, 1993

We have examined Insulln-like growth factor 1 receptor (IGF1R) gene expression for evidence of Imprinting in 15 informative patients with embryonal tumours. Blallellic expression was observed In all but one sample of normal juvenlle kidney and liver, and In 9/10 associated Wllms' tumours, 3/3 hepatoblastomas and 2/2 adrenal tumours. A single patient with Beckwlth—Wledemann Syndrome (BWS) demonstrated monoallellc expression of the maternally derived IGF1R allele In normal kidney, associated Wllms' tumour and In peripheral blood lymphocytes. The observed blallellc expression of the IGF1R gene in all but one patient strongly suggests that the human gene Is not normally Imprinted.


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