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© 1993 Oxford University Press

OTHER

Loss of the ‘azoospermia factor’ (AZF) on Yq in man is not associated with loss of HYA

Elizabeth Simpson*, Phillip Chandler, Els Goulmy1, Kun Ma2, Timothy B. Hargreave3 and Ann C. Chandley2

Transplantation Biology, Clinical Research Centre Watford Road, Harrow, Middlesex HA1 3UJ, UK 1Department of Immunohaematology and Blood Bank AZL, Postbus 9600, 2300 RC Leiden, The Netherlands 2MRC Human Genetics Unit, Western General Hospital Crewe Road, Edinburgh EH4 2XU, UK 3Department of Urology, Western General Hospital Crewe Road, Edinburgh EH4 2XU, UK

* To whom correspondence should be addressed

Received November 16, 1992; Revised January 22, 1993; Accepted January 22, 1993

We have typed 9 EBV cell lines from azoospermic or severely oligospermic patients for the expression of H-Y antigen, in order to test the hypothesis of the coincidence of AZF and HYA genes. Of nine patients with cytogenetically normal Y chromosomes, 7 could be tested for HYA expression and of these 6 were H-Y positive. Of the three patients showing Yq structural abnormalities, two could be tested for H-Y expression and one was negative, the other positive. These results therefore show no correlation between spermatogenic failure and the absence of HYA, thus separating the AZF locus from HYA.


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