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© 1993 Oxford University Press

OTHER

A gene from chromosome 4p 16.3 with similarity to a superfamily of transporter proteins

Mabel P. Duyao, Sherryl A.M. Taylor, Alan J. Buckler, Christine M. Ambrose, Carol Lin, Nicolet Groot, Deanna Church, Glenn Barnes, John J. Wasmuth1, David E. Housman2, Marcy E. MacDonald and James F. Gusella*,

Molecular Neurogenetics Unit, Massachusetts General Hospital and Department of Genetics, Harvard Medical School Boston, MA 02114 1Department of Biological Chemistry, University of California Irvine, CA 92717 2Center for Cancer Research, Massachusetts Institute of Technology Cambridge MA, USA

* To whom correspondence should be addressed

Received February 24, 1993; Revised April 12, 1993; Accepted April 12, 1993

We have previously used exon amplification to identify the ADD1 gene in cosmid Y24 from the Huntington's disease (HD) region of 4p16.3. The same technique has now yielded a second gene from this cosmid. This gene appears to encode a novel member of a superfamily of transporter proteins that includes active and passive transporters in a number of species. The predicted protein of 455 amino acids displays sequence similarity with the E.coli tetracycline resistance efflux protein encoded by cloning vector pBR322, and with a number of related transporters. This gene should open a route to isolating additional mammalian members of this growing superfamily.


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