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© 1993 Oxford University Press

OTHER

The cloning and expression of a sodium channel ß1-subunit cDNA from human brain

Andrea I. McClatchey, Stephen C. Cannon1, Susan A. Slaugenhaupt and James F. Gusella*,

Molecular Neurogenetics Unit, Massachusetts General Hospital and Department of Genetics, Harvard Medical School Charlestown MA 02129 1Howard Hughes Medical Institute and Department of Neurology, Massachusetts General Hospital and Harvard Medical School Boston, MA 02114, USA

* To whom correspondence should be addressed at: Molecular Neurogenetics Unit, Massachusetts General Hospital East, Building 149,13th Street Charlestown, MA 02129, USA

Received February 2, 1993; Revised April 12, 1993; Accepted April 12, 1993

Electrical excitability of neurons and muscle cells is mediated largely through the actions of the voltage-gated sodium channel. Initiation and propagation of the action potential is a direct result of the precisely controlled inward flux of sodium through these channels. Much attention has been paid to the sodium channel {alpha}-subunit, the major, pore-forming component. However, {alpha}-subunits are associated with one or more smaller ß-subunits, which have been implicated in the critical fine tuning of the gating properties of the channel. To investigate the properties of the ß-subunit, we have isolated a cDNA encoding the human brain ß1-subunit and assigned the corresponding gene to chromosome 19. We have also examined the effects of expressing the brain ß1-subunit on the kinetics of a coexpressed muscle sodium channel {alpha}-subunit. Our results underscore the functional importance of the ß1-subunit and imply a conserved mechanism for the interaction of the ß1-subunit with different {alpha}-subunits.


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