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© 1993 Oxford University Press

OTHER

Refined localization and yeast artificial chromosome (YAC) contig—mapping of genes and DNA segments in the 7q21–q32 region

Stephen W. Scherer1,2, Johanna M. Rommens2, Sylvia Soder2, Ed Wong2, Natasa Plavsic2, Brock J.F. Tompkins2, Aaron Beattie2, Julia Kim2 and Lap-Chee Tsui1,2,*

1Department of Molecular and Medical Genetics, University of Toronto Toronto, Ontario M5S 1A8 2Department of Genetics, Research Institute, The Hospital for Sick Children Toronto, Ontario M5G 1X8, Canada

* To whom correspondence should be addressed at: Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada

Received January 29, 1993; Revised April 11, 1993; Accepted April 11, 1993

The chromosome localizations for 159 gene and DNA segments have been refined to one of five intervals in the 7q21–q32 region through hybridization analysis with a panel of somatic cell hybrid lines. Seventy-two of these chromosome 7 markers are also mapped on common or overlapping yeast artificial chromosome (YAC) clones. In addition, the breakpoints of chromosome rearrangment contained in five of the somatic cell hybrid lines have been defined by flanking probes within YAC contigs. To provide a framework for further mapping of the 7q21–q32 region, we have established the physical order of a set of reference markers: cen-(COL1A2-D7S15-CYP3A4-PON)-D7S456-(breakpoint contained in cell hybrid 1EF2/3/K017)-GUSB-D7S186-ASL-(PGY1-PGY3-GNB2-EPO-ACHE)-D7S238-(proximal breakpoint in GM1059-Rag5)-D7S240-(CUTL1-PLANHI)-(breakpoints in 1CF2/5/K016 and 2068Rag22–2)-(PRKAR2B-D7S13)-LAMB1-(breakpoint in JSR-17S)-DLD-D7S16-MET-WNT2-CFTR-D7S8-tel.


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