Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bucan, M.
Right arrow Articles by Budarf, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bucan, M.
Right arrow Articles by Budarf, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 Oxford University Press

RESEARCH-ARTICLE

Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse

Maja Bucan*, Biljana Gatalica, Patrick Nolan, Alice Chung, Alena Leroux1, Mark H. Grossman2, Joseph H. Nadeau3, Beverly S. Emanuel4 and Marcia Budarf

Department of Psychiatry, University of Pennsylvania Philadelphia, PA 19104, USA 1Institut Cochin De Genetique Moteculaire, INSERM, U 129, 24 rue du Faubourg Saint-Jacques Pans, 75014, France 2Department of Pediatrics, Temple University School of Medicine, St Christopher' Hospital for Children, Philadelphia, PA 19134 3Jackson Laboratory, Bar Harbor, Maine, ME 04609 and 4The Children' Hospital of Philadelphia Philadelphia, PA 19104, USA 4The Children's Hospital of Philadelphia Philadelphia, PA 19104, USA

* To whom correspondence should be addressed at: University of Pennsylvania, 111A CRB, 422 Curie Blvd., Philadelphia, PA 19104–6141, USA

Received February 19, 1993; Revised May 18, 1993; Accepted May 18, 1993

We present a comparative map of genes on human chromosome 22q and homologous loci In the mouse genome. Gene order in humans was established using a panel of somatic cell hybrids. Genetic maps spanning homologous segments on three mouse chromosomes were generated using an Interspecific backcross. The conserved linkage between human chromosome 22 and mouse chromosome 16 Includes two closely linked loci, Comt and Igl-1. The second conserved linkage involves human chromosome 22 and mouse chromosome 11 and contains two genetically and physically linked loci, Lif and Nfh. Finally, conserved synteny involving mouse chromosome 15 and human chromosome 22 spans 30 cM and contains five loci (Acr, Bzrp, Dia-1, II2rb and Pdgfb). Loci within this conserved synteny have been sublocalized to different portions of human chromosome 22. The order of genes on mouse chromosome 15 and human chromosome 22 provides further evidence for chromosomal rearrangements within the conserved synteny that have occurred since the divergence of lineages leading to mice and humans.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
F. R. van der Leij, K. B. Cox, V. N. Jackson, N. C. A. Huijkman, B. Bartelds, J. R. G. Kuipers, T. Dijkhuizen, P. Terpstra, P. A. Wood, V. A. Zammit, et al.
Structural and Functional Genomics of the CPT1B Gene for Muscle-type Carnitine Palmitoyltransferase I in Mammals
J. Biol. Chem., July 19, 2002; 277(30): 26994 - 27005.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Goldmuntz and B. S. Emanuel
Genetic Disorders of Cardiac Morphogenesis : The DiGeorge and Velocardiofacial Syndromes
Circ. Res., April 19, 1997; 80(4): 437 - 443.
[Full Text]

Home page
 Genome ResHome page
N Galili, H S Baldwin, J Lund, R Reeves, W Gong, Z Wang, B A Roe, B S Emanuel, S Nayak, C Mickanin, et al.
A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region.
Genome Res., January 1, 1997; 7(1): 17 - 26.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.