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© 1993 Oxford University Press

RESEARCH-ARTICLE

The major centromeric array of alphoid satellite DNA on the human Y chromosome is non-palindromic

Katrina F. Cooper+, Richard B. Fisher§ and Chris Tyler-Smith*

CRC Chromosome Molecular Biology Group, Department of Biochemistry, University of Oxford South Parks Road, Oxford OX1 3QU, UK

* To whom correspondence should be addressed

Received October 8, 1992; Revised May 17, 1993; Accepted May 17, 1993

We have determined the orientation of the major centromeric alphoid array on the human Y chromosome. A PCR assay was used to analyse the vector-insert junctions of seven YAC clones previously positioned on two independent Y chromosomes. The orientation is the same at all 10 positions measured. This suggests that the alphoid array is a simple unidirectional repeat throughout and that human centromere structure thus differs from the palindromic organisation found in Schizosaccharomyces pombe.

Present addresses: +Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, USA

§Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK


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