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© 1994 Oxford University Press

OTHER

A heat shock gene at 14q22: mapping and expression

Anne-Françoise Roux1, T.T. Van Nguyen1, Jeremy A. Squire2 and Diane W. Cox1,3,*

1Departments of Genetics, The Hospital for Sick Children Toronto, Ontario 2Departments of Pathology, The Hospital for Sick Children Toronto, Ontario 3Department of Molecular and Medical Genetics, University of Toronto Toronto, Ontario, Canada

*Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G IX8, Canada

Received June 10, 1994; Revised July 29, 1994; Accepted July 29, 1994

Heat shock proteins (HSP) belong to a family of highly homologous proteins that are encoded by several genes and function as protein chaperones. A number of HSP genes have been described in the major histocompatibility complex (MHC) on chromosome 6. We have cloned and mapped one chromosome 14 HSP gene (HSPA2) using a genomic probe (pH2.3) derived from one of the HSP genes present in the MHC, which was previously shown to also detect sequences on chromosome 14. Screening of a chromosome 14-specific cosmid library yielded one relevant clone that contains an HSP-like sequence, showing a high degree of identity with the HSP genes from the MHC and with HSP70.2 (Hspa2) in the mouse. This new HSP gene is expressed abundantly in muscle, heart, oesophagus and brain, and to a lesser extent in testis. Its localization to 14q22 was established by using a somatic cell hybrid panel and FISH analysis. A pentanucleotide repeat motif, showing seven alleles, was also identified in the cosmid clone.


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