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© 1994 Oxford University Press

OTHER

Construction of human Y-chromosomal haplotypes using a new polymorphic A to G transition

Mark T. Selelstad1,2,*, Joan M. Hebert2, Alice A. Lin2, Peter A. UnderhllI2, Muntaser Ibrahlm3, Douglas vollrath2 and L.Luca Cavalll-Storza2

1Department of Organismtc and Evolutionary Biology, Harvard University Cambridge, MA 02138 2Department of Genetics, Stanford University Stanford, CA 94305, US 3lnstrtute for MedicaJ Microbiology and Immunology, Copenhagen Denmark

*To whom correspondence should be addressed

Received July 21, 1994; Accepted October 7, 1994

We report the discovery of a polymorphic A to G transition found on the human Y chromosome by sequencing Y-specific sequence-tagged sites (STSs). It shows maximal linkage disequilibrium with a previously described Alu insertional polymorphism. We analyze further an apparently African Y chromosome which seems to have entered a Mexican Mayan population several generations ago. Using the newly discovered transition and the Y-speclfic polymorphic Alu insertion, we discuss how the chromosome's haplotype information might be used to answer questions of houman origins and migrations.


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