Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (79)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Chaib, H.
Right arrow Articles by Petit, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chaib, H.
Right arrow Articles by Petit, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1994 Oxford University Press

OTHER

A gene responsible for a dominant form of neurosensory non-syndromic deafness maps to the NSRD1 recessive deafness gene interval

Hassan Chaib, Geneviéve Lina-Granade1, Parry Guilford, Henri Plauchu2, Jacqueline Levilliers, Alain Morgon1 and Christine Petit*

Unité de Génétique Moléculaire Humane, URA CNRS 1445, Instrtut Pasteur 25 rue du Dr Roux, 75724 Paris Cedex 15 1Laboratoire de Physjotogie Sensorieile, URA CNRS 1447 and Université Claude Bernard Lyon I, Département d‘ORL, Hospital E.Herriot 69437 Lyon Cedex 03 2Service de Génée, Hospital E.Herrot, 69437 Lyon Cedex 03 France

*To whom correspondence should be addressed

Received August 24, 1994; Accepted October 4, 1994

The first localization of a gene responsible for autosomal, neurosensory, recessive deafness recently assigned NSRD1 to the centromeric region of human chromosome 13. We now report on a dominant form of neurosensory deafness found In a family of French origin. The deafness is moderate to severe, has a prellngual onset and affects predominantly the high frequencies. The gene responsible for this form of deafness was found by linkage analysis to map to the same region of chromosome 13 as NSRD1. A multipoint analysis gave a maximum lod score of 4.66 with a most likely location close to locus D13S175. This suggests that different mutations in NSRD1 may cause both dominant and recessive neurosensory deafness.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
J. C. SAEZ, V. M. BERTHOUD, M. C. BRANES, A. D. MARTINEZ, and E. C. BEYER
Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions
Physiol Rev, October 1, 2003; 83(4): 1359 - 1400.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
G. Van Camp, H. Kunst, K. Flothmann, W. McGuirt, J. Wauters, H. Marres, M. Verstreken, I. N Bespalova, M. Burmeister, P. H Van de Heyning, et al.
A gene for autosomal dominant hearing impairment (DFNA14) maps to a region on chromosome 4p16.3 that does not overlap the DFNA6 locus
J. Med. Genet., July 1, 1999; 36(7): 532 - 536.
[Abstract] [Full Text]

Home page
 Genome ResHome page
B. J. B. Keats and C. I. Berlin
Genomics and Hearing Impairment
Genome Res., January 1, 1999; 9(1): 7 - 16.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.