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© 1994 Oxford University Press

RESEARCH-ARTICLE

Human immunoglobulin VH and D segments on chromosomes 15q11.2 and 16p11.2

M.Tomlinson Ian1,2, Graham P. Cook1,2,*, P.Carter Nigel3, Ramnath Elaswarapu4, Sarah Smith4, Gerald Walter1,2,+, Lakjaya Buluwela1,§, Terence H. Rabbitts1 and Greg Winter1,2

1MRC Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH, UK 2MRC Centre for Protein Engineering Hills Road, Cambridge CB2 2QH, UK 3Cambridge University Department of Pathology Tennis Court Road, Cambridge CB2 1QP, UK 4MRC Clinical Research Centre Northwick Park, Watford Road, Harrow, Middlesex HA1 3UJ, UK

* To whom correspondence should be addressed

Received February 24, 1994; Revised April 11, 1994; Accepted April 11, 1994

In addition to the major human immunoglobulin heavy-chain locus on chromosome 14q32.3, VH and D segments are known to be present on chromosomes 15 and 16, We have now amplified and sequenced 24 such VH segments from somatic cell hybrids and have assigned them to 15q11.2 and 16p11.2 using cosmid and yeast artificial chromosome clones. In addition, we have located a cluster of D segments on 15q11.2, previously thought to be located on 14q32.3. We propose that the segments on chromosome 16 arose by an interchromosomal duplication and identify the corresponding region on chromosome 14. Taken together with the completion of a map of the human VH locus on 14q32.3, the total number of VH segments now identified is 117. We can now account for most, if not all human germ-line VH segments.

+ Cambridge Antibody Technology, Science Park, Melbourn, Cambrigeshire SG8 6EJ

§ Department of Biochemistry, Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, UK


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