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© 1994 Oxford University Press

OTHER

TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12

Robert N. Haire, Yuko Ohta, Janet E. Lewis1, Shu Man Fu1, Peter Kroisel2 and Gary W. Litman*

Department of Pediatrics, University of South Florida, All Children's Hospital 801 Sixth Street South, St Petersburg, FL 33701, USA 1Department of Internal Medicine, University of Virginia Box 412, Charlottesville, VA 22908, USA 2Institute for Medical Biology and Human Genetics, University of Graz Harrachgasse 21/8, A-8010 Graz, Austria

*To whom correspondence should be addressed

Received January 31, 1994; Revised April 8, 1994; Accepted April 8, 1994

A gene for a novel, putative cytoplasmic tyrosine kinase, TXK has been isolated from a human peripheral blood cDNA library. The complete nucleotide sequence of the cDNA indicates that it is related most closely to EMT, a tyrosine kinase of T cells and to the B-cell tyrosine kinase Btk, which is mutated in X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency disease (XID) in mouse. TXK, like BTK, is a member of the Tec sub-family of Src-type (non-receptor) tyrosine kinases. Like similar Tec subfamily members, and unlike the other Src kinases, TXK lacks both the N-terminal myristylation signal and the C-terminal regulatory tyrosine. TXK expression is detected primarily in T cells and some myeloid cell lines but not in a number of other cell types. TXK shares 60% amino acid homology with EMT and 57% with BTK over the SH3, SH2 (Src-homology) and catalytic domains but unlike BTK, EMT and tec, it lacks Gap 1 homology and steroid hormone receptor homology in the N-terminal region. Genomic clones containing TXK have been isolated and hybridize to chromosome position 4p12.


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