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© 1994 Oxford University Press

OTHER

Alternative transcripts in the mouse neurofibromatosis type 2 (NF2) gene are conserved and code for schwannomins with distinct C-terminal domains

Duong P. Huynh, Tamilla Nechiporuk and Stefan-M. Pulst*

Neurogenetics Laboratory and Division of Neurology, Cedars-Sinai Medical Center, UCLA School of Medicine 8700 Beverty Boulevard, Los Angeles, CA 90048, USA

*To whom correspondence should be addressed

Received February 14, 1994; Revised May 13, 1994; Accepted May 13, 1994

Mutations in the neurofibromatosis type 2 (NF2) gene predispose individuals to the development of nervous system tumors and ocular abnormalities. The NF2 gene product, schwannomin, is a member of a superfamily of proteins thought to link cytoskeletal elements to cell membrane components. These proteins share significant homologles in the N-terminal and {alpha}-helical domains, but diverge in the C-terminus. During our efforts to characterize mouse NF2 transcripts, we identified four different transcripts by cDNA analysis and reverse-transcribed PCR that contained different sequences in the 3' end of the coding sequences. In human cell lines three isoforms encoding two distinct schwannomins were detected. The mouse and human transcripts containing 61 and 60 bp inserts, respectively, have not been previously described. The isoforms encode schwannomins with significantlly altered C-Termini and were expressed at different relative levels in adult mouse tissues and during mouse embryogenesis. These results suggest that schwannomin isoforms have distinct functional roles and predict the existence of human mutations involving the C-terminus of schwannomin.


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