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© 1994 Oxford University Press

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Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6

Anand Swaroop1,2,3,*, Teresa L. Yang-Feng4, Wanguo Liu5, Linn Gieser1, Lon L. Barrow2, Kuang-Chao Chen4, Neeraj Agarwal6, Miriam H. Meisler2,3 and David I. Smith5,*

1Departments of 1Ophthalmology 2Human Genetics 3Human Genome Center, University of Michigan Ann Arbor, Ml 48109–0618 4Department of Genetics, Yale University School of Medicine New Haven, CT 06510 5Department of Internal Medicine, Wayne State University School of Medicine Detroit Ml 48201 6Department of Anatomy and Cell Biology, University of North Texas Health Science Center Fort Worth, TX 76107, USA

*To whom correspondence should be addressed

Received June 6, 1994; Accepted June 6, 1994

We previously described sequence tags from 58 novel dlrectionally cloned human cDNAs from an enriched retinal pigment epithelial cell line library (Gleser and Swaroop, 1992). The nucleotlde sequence of one of the cDNA clones, AA35 (D3S1231E), showed strong homology to the yeast SEC13 gene, required for vesicle biogenesis from endoplasmic retlculum during the transport of proteins. We have designated the human gene SEC13R (SEC13-Related). The amino acid sequence of the SEC13R gene product shows 70% similarity to yeast Sec13p, suggesting that SEC13R may be the human homolog of SEC13. The deduced polypeptide sequence contains several ß-transducin like ‘WD40’ repeats, and Is rich In serine and threonlne residues. The 1.4 kb transcript of SEC13R is detected by Northern analysis in many human tissues. However, RT - PCR analysis using two primer sets from different regions of the gene suggests differential expression of alternately spliced transcripts in various tissues. Somatic cell hybrid and in situ hybridization studies localized the SEC13R gene to human chromosome 3p24-p25. A related sequence was mapped to chromosome 18q11.2-q12. SEC13R was physically mapped to a yeast artificial chromosome (YAC) clone spanning the D3S720 marker from the region of the Von Hlppel - Lindau disease locus. The mouse Sec13r gene was mapped to the conserved linkage group on chromosome 6 that corresponds to human chromosome 3p24-p25.


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