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© 1994 Oxford University Press

OTHER

Linkage of a new locus for autosomal dominant familial spastic paraplegia to chromosome 2p

Jamilé Hazan1,, Bertrand Fontaine1,2, Richard P.M. Bruyn3, Catherine Lamy4, Judith C.T. van Deutekom5, Clalre-Sophie Rime1, Alexandra Dürr2,6, Judith Melkl8, Olivier Lyon-Caen2,7, Yves Agid2,6, Arnold Munnich8, George W. Padberg9, Jean de Recondo4, Rune R. Frants5, Alexis Brice2,6 and Jean Welssenbach*

Unité de Génétique Moléculaire Humaine, CNRS URA1445, Institut Pasteur 25 rue du Docteur Roux, 75724 Paris Cedex 15 1INSERM U134 H{odot}pital de la Salpetrière 47 Bd de I'H{odot}pital, 75013 Paris, France 2Fédération de Neurologie, Hupital de la Salptrière 47 Bd de I'H{odot}pital, 75013 Paris, France 3Department of Neurology, Oudennjn Hospital Utrecht Netherlands 4Service de Neurologie, Centre Raymond Garcin, Hupital Ste-Anne 1 rue Cabanis, 75674 Paris Cedex 14, France 5MGC-Department of Human Genetics, Leiden University Leiden Netherlands 6INSERM U298, Hupital de la Salpetrière 47 Bd de l'H{odot}pital, 75013 Paris 7INSERM U360, Hupital de la Salpetrière 47 Bd de l'H{odot}pital, 75013 Paris 8INSERM U393, H{odot}pital Necker 149 rue de Sèvres, 75743 Paris Cedex 15, France 9Department of Neurology, Nijmegen University Nijmegen, Netherlands

* To whom correspondence should be addressed

Received April 13, 1994; Revised June 29, 1994; Accepted June 29, 1994

Autosomal dominant familial spastic paraplegia (ADFSP) is a genetically heterogeneous neurodegenerative disorder characterized by a spasticity of the lower limbs. A locus causing AD-FSP (FSP1) has been previously mapped to chromosome 14q. We now report linkage of a second AD-FSP locus (FSP2) to chromosome 2p21 – p24 In five of seven French families and one large Dutch pedigree. The analysis of recombination events and multipoint linkage place FSP2 within a 4 cM interval flanked by loci D2S400 and D2S367.


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